論文

2017年

Original Articles

  1. Kondo T, Ikenaka Y, Nakayama SMM, Kawai YK, Mizukawa H, Mitani Y, Nomiyama K, Tanabe S,  Ishizuka M. UDP-glucuronosyltransferase (UGT) 2B subfamily interspecies differences in carnivores. Tox. Sci. 158: 90-100 (2017) DOI: 10.1093/toxsci/kfx072
  2. Ishii C,  Nakayama SMM, Ikenaka Y, Nakata H, Saito K, Watanabe Y, Mizukawa H, Tanabe S, Nomiyama K, Hayashi T, Ishizuka M. Lead exposure in raptors from Japan and source identification using Pb stable isotope ratios. Chemosphere. 186: 367-373 (2017) DOI: 10.1016/j.chemosphere.2017.07.143
  3. Kobayashi S, Sata F, Miyashita C, Miura R, Azumi K, Kobayashi S, Goudarzi H, Araki A, Ishizuka M, Todaka T, Kajiwara J, Hori T, Kishi R. Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study. Toxicology. 390: 135-145 (2017) DOI: 10.1016/j.tox.2017.08.010
  4. Mizukawa H, Nomiyama K, Nakatsu S, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama SMM, Tanabe S. Anthropogenic and Naturally Produced Brominated Phenols in Pet Blood and Pet Food in Japan. Environ. Sci. Technol. 51(19): 11354-11362 (2017) DOI: 10.1021/acs.est.7b01009
  5. Yohannes YB, Ikenaka Y, Gengo I, Nakayama SMM, Mizukawa H, Victor Wepener N, Smit NJ, van Vuren JJ, Ishizuka M. Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa. Environmnetal Science and Pollution Research  (2017, in press) DOI: 10.1007/s11356-017-9911-7
  6. Thompson LA, Ikenaka Y, Yohannes YB, van Vuren JJ, Wepener V, Smit NJ, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M. Concentrations and Human Health Risk Assessment of DDT and Its Metabolites in Free-range and Commercial Chicken Products from KwaZulu-Natal, South Africa. Food Additives and Contaminants: Part A. 34(11): 1959-1969 (2017) DOI: 10.1080/19440049.2017.1357209
  7. M’kandawire E, Choongo K, Yabe J, Mwase M, Saasa N, Nakayama SMM, Bortey-Sam N, Blindauer. Sediment Metal Contamination in the Kafue River of Zambia and Ecological Risk Assessment. Bulletin of Environmental Contamination and Toxicology. (2017, in press) DOI: 10.3390/ijerph14010056
  8. Kobayashi S, Azumi K, Goudarzi H, Araki A, Miyashita C, Kobayashi S, Itoh S, Sasaki S, Ishizuka M, Nakazawa H, Ikeno T, Kishi R. Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido Study. Journal of Exposure Science and Environmental Epidemiology. 27:251-259 (2017) DOI: 10.1038/jes.2016.50
  9. 水川葉月、池中良徳、筧麻友、中山翔太、石塚真由美:非実験動物における化学物質代謝能の特徴と種差 Characterization of species differences of xenobiotic metabolism in non-experimental animals. YAKUGAKU ZASSHI 137(2017)
  10. Ishii C, Ikenaka Y, Nakayama SMM, Mizukawa H, Yohannes YB, Watanuki Y, Fukuwaka M, Ishizuka M. Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea. JVMS (2017, in Press) DOI: 10.1292/jvms.16-0441
  11. Thompson LA, Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Organochlorine pesticide contamination of foods in Africa: incidence and public health significance. JVMS (2017, in Press) DOI: 10.1292/jvms.16-0214
  12. Nakata H*, Nakayama SMM*, Oroszlany B, Ikenaka Y, Mizukawa H, Tanaka K, Harunari T, Tanikawa T, Darwish WS, Yohannes YB, Saengtienchai A, Ishizuka M (* Equal contribution). Monitoring lead (Pb) pollution and identifying Pb pollution sources in Japan using stable Pb isotope analysis with kidney of wild rats. Int. J. Environ. Res. Public Health (2017, in Press) DOI: 10.3390/ijerph14010056
  13. Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Trace Element Contamination in Tissues of Four Bird Species from the Rift Valley Region, Ethiopia. BECT (2017, in Press) DOI: 10.1007/s00128-016-2011-4
  14. Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia. Sci. Total. Environ. 574: 1389-1395 (2017) DOI: 10.1016/j.scitotenv.2016.08.056

▲このページの先頭へ

2016年

Original Articles

  1. Takeda K*, Ikenaka Y*, Tanikawa T, Tanaka KD, Nakayama SMM, Mizukawa H, Ishizuka M (*Equal contribution). Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis. Pestic Biochem Physiol. (2016, in press) DOI: 10.1016/j.pestbp.2016.04.004
  2. Saengtienchai A, Ikenaka Y, Bortey-Sam N, Jermnark U, Mizukawa H, Kawai YK, Nakayama SMM, Ishizuka M. The African hedgehog (Atelerix albiventris): low phase I and phase II metabolism activities. Comp Biochem Physiol C Pharmacol Toxicol. 190: 38-47 (2016) DOI: 10.1016/j.cbpc.2016.08.005
  3. Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo J, Saengtienchai A, Mizukawa H, Ishizuka, M. Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana. Environmental Pollution. 218: 331-337 (2016) DOI: 10.1016/j.envpol.2016.07.008
  4. Bortey-Sam N*, Nakayama SMM*, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Heavy metals and metalloid accumulation in livers and kidneys of wild rats around gold-mining communities in Tarkwa, Ghana. Journal of Environmental Chemistry and Ecotoxicology, 8(7), pp.58-68 (2016) DOI: 10.5897/JECE2016.0374
  5. Nakayama SMM,  Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M. Characterization of Equine Cytochrome P450: Role of CYP3A in the Metabolism of Diazepam. Journal of Veterinary Pharmacology and Therapeutics.  39(5):478-87 (2016) DOI: 10.1111/jvp.12303
  6. Watanuki Y, Yamashita A, Ishizuka M, Ikenaka Y, Nakayama SMM, Ishii C, Yamamoto T, Ito M, Kuwae T, Trathan PN. Feather mercury concentration in streaked shearwaters wintering in separate areas of Southeast Asia. Mar Ecol Prog Ser. 546: 263-269 (2016) DOI: 10.3354/meps11669
  7. Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Constitutive Effects of Lead on Aryl Hydrocarbon Receptor Gene Battery and Protection by β-carotene and Ascorbic Acid in Human HepG2 Cells. J. Food. Sci. 81(1):T275-81 (2016) DOI: 10.1111/1750-3841.13162
  8. Gerber R, Smit NJ, Van Vuren JH, Nakayama SMM, Yohannes YB, Ikenaka Y, Ishizuka M, Wepener V. Bioaccumulation and human health risk assessment of DDT and other organochlorine pesticides in an apex aquatic predator from a premier conservation area. Sci. Total. Environ. 550: 522-533 (2016) DOI: 10.1016/j.scitotenv.2016.01.129
  9. Nishiyama Y, Nakayama SMM, Watanabe KP, Kawai YK, Ohno M, Ikenaka Y, Ishizuka M. Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats. JVMS. 78.4: 675-80 (2016) DOI: 10.1292/jvms.15-0299
  10. Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama S, Kunisue T, Tanabe S. Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances? Environ. Sci. Technol. 50(1):444-52 (2016) DOI: 10.1021/acs.est.5b04216
  11. Nakata H*, Nakayama SMM*, Yabe J, Liazambi A, Mizukawa H, Darwish WS, Ikenaka Y, Ishizuka M (* Equal contribution). Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens. Environ Pollut. 208(Pt B):395-403 (2016) DOI: 10.1016/j.envpol.2015.10.006
  12. Mahmoud AFA, IkenakaY, YohannesYB, DarwishWS, Eldaly EA, Morshdy AE, Nakayama SMM, MizukawaH, Ishizuka M. Distribution and health risk assessment of organochlorine pesticides (OCP) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCP in tongue. Chemosphere 144:1365-71 (2016) DOI: 10.1016/j.chemosphere.2015.10.016
  13. Darwish WS, Ikenaka Y, Morshdy AE, Eldesoky KI, Nakayama SMM, MizukawaH, Ishizuka M. β-carotene and retinol contents in the meat of herbivorous ungulates with a special reference to their public health importance. JVMS. 78.2: 351 (2016) DOI: 10.1292/jvms.15-0287

▲このページの先頭へ

2015年

Original Articles

  1. Yoo J, Hirano M, Mizukawa H, Nomiyama K, Agusa T, Kim E-Y, Tanabe S, Iwata H. In vitro and in silico analyses for predicting hepatic cytochrome P450-dependent metabolic potencies of polychlorinated biphenyls in the Baikal seal.  Environ. Sci. Technol. 49(24):14588-96 (2015) DOI: 10.1021/acs.est.5b03890
  2. Marfo JT *, Fujioka K*, Ikenaka Y, Nakayama SMM, Mizukawa H, Aoyama Y, Ishizuka M, Taira K (*Equal contribution). Relationship between urinary N-desmethyl-acetamiprid and typical symptoms including neurological findings: A prevalence case-control study. PlosONE 10(11):e0142172 (2015) DOI: 10.1371/journal.pone.0142172
  3. Teraoka H, Okamoto E, Kudo M, Nakayama SMM, Ikenaka Y, Ishizuka M, Endo T, Kitazawa T, Hiraga T. Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan. Ecotoxicology and Environmental Safety. 122:557-564 (2015) DOI: 10.1016/j.ecoenv.2015.09.025
  4. Bortey-Sam N*, Nakayama SMM*, Akoto O, Ikenaka Y, Fobil N.J., Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Ecological Risk of Heavy Metals and a Metalloid in Agricultural Soils in Tarkwa, Ghana. Int J Environ Res Public Health. 12(9):11448-11465 (2015) DOI: 10.3390/ijerph120911448
  5. Gerber R, Smit N, van Vuren J, Nakayama SMM, Yohannes YB, Ikenaka Y, Ishizuka M, Wepener V. Application of a Sediment Quality Index for the assessment and monitoring of metals and organochlorines in a premier conservation area. Environ Sci Pollut Res. 22(24):19971-19989 (2015) DOI: 10.1007/s11356-015-5206-z
  6. Bortey-Sam N*, Nakayama SMM*, Akoto O, Ikenaka Y, Fobil N.J., Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Accumulation of heavy metals and metalloid from agricultural soils to foodstuffs around Tarkwa area in Ghana, and associated human health risks. Int J Environ Res Public Health. 12(8):8811-8827 (2015) DOI: 10.3390/ijerph120808811
  7. Watanabe KP, Kawata M, Ikenaka Y, Nakayama  SMM, Ishii C, Darwish WS, Saengtienchai A, Mizukawa H, Ishizuka M. Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken. Environ Toxicol Chem. 34(10):2328-2334 (2015) DOI: 10.1002/etc.3062
  8. Kakehi M, Ikenaka Y, Nakayama  SMM, Kawai YK, Watanabe KP, Mizukawa H, Nomiyama K, Tanabe S, Ishizuka M. Uridine diphosphate-glucuronosyltransferase (UGT) xenobiotic metabolizing activity and genetic evolution in Pinniped species. Tox Sci. 147(2):360-9 (2015) DOI: 10.1093/toxsci/kfv144
  9. Bortey-Sam N*, Nakayama  SMM*, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Health risk assessment of heavy metals and metalloid in drinking water from communities near gold mines in Tarkwa, Ghana. Environ Monit Assess, 187(7):1-12 (2015) DOI: 10.1007/s10661-015-4630-3
  10. Darwish WS, Nakayama SMM, Itotani Y, Ohno M, Ikenaka Y, Ishizuka M. Metabolic Activation of Heterocyclic Amines and Expression of Xenobiotic-Metabolizing Enzymes in the Gastrointestinal Tract of Rats. J Food Sci, 80(7):T1627-T1632 (2015) DOI: 10.1111/1750-3841.12931
  11. Darwish WS, Hussein MA, El-Desoky KI, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Incidence and public health risk assessment of toxic metal residues (cadmium and lead) in Egyptian cattle and sheep meats. Int Food Res J, 22(4):1719-1726 (2015)
  12. Nakata H*, Nakayama SMM*, Ikenaka Y, Mizukawa H, Ishii C, Yohannes YB, Konnai S, Darwish WS, Ishizuka M (* Equal contribution). Metal extent in blood of livestock from Dandora dumping site, Kenya: source identification of Pb exposure by stable isotope analysis. Environ Pollut. 205:8-15 (2015) DOI: 10.1016/j.envpol.2015.05.003
  13. Saengtienchai A, Ikenaka Y, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M. Characterization and tissue distribution of conjugated metabolites of pyrene in the rat. J Vet Med Sci. 77(10):1261-1267 (2015) DOI: 10.1292/jvms.14-0632
  14. Ikenaka Y, Nakayama SMM, Oguri M, Saengtienchai A, Mizukawa H, Kobayashi J, Darwish WS, Ishizuka M. Are red gourami (Colisa labiosa) low xenobiotic metabolizers? Elucidation of in vivo pharmacokinetics of pyrene as a model substrate. Environ Toxicol Pharmacol, 39:1148-1153 (2015) DOI: 10.1016/j.etap.2015.04.004
  15. Mizukawa H, Nomiyama K, Kunisue T, Watanabe MX, Subramanian A, Iwata H, Ishizuka M, Tanabe S. Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P450. Environ Res, 138:255-263 (2015) DOI: 10.1016/j.envres.2015.02.012
  16. Watanuki Y, Yamamoto T, Yamashita A, Ishii C, Ikenaka Y, Nakayama SMM, Ishizuka M, Suzuki Y, Niizuma Y, Meathrel CE, Phillips RA. Mercury concentrations in primary feathers reflect pollutant exposure in discrete non-breeding grounds used by Short-tailed Shearwaters. Journal of Ornithology, 156:847-850 (2015) DOI: 10.1007/s10336-015-1205-6
  17. Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama M.M.S, Yared YB, Baidoo E, Mizukawa H, Ishizuka M. Levels, potential sources and human health risk of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in Kumasi-Ghana. Environ Sci Pollut Res, Jul;22(13):9658-67 (2015) DOI: 10.1007/s11356-014-4022-1
  18. Yabe J*, Nakayama SMM*, Ikenaka Y, Yohannes YB, Bortey-Sam N, Oroszlany B, Muzandu K, Choongo K, Kabalo AN, Ntapisha J, Mweene A, Umemura T, Ishizuka M (* Equal contribution). Lead poisoning in children from townships in the vicinity of a lead-zinc mine in Kabwe, Zambia. Chemosphere, 119:941-947 (2015) DOI: 10.1016/j.chemosphere.2014.09.028
  19. Bortey-Sam N*, Nakayama SMM*, Ikenaka Y, Akoto O, Yohannes YB, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Human health risks from metals and metalloid via consumption of food animals near Gold Mines in Tarkwa, Ghana: Estimation of the daily intakes and target hazard quotients (THQs). Ecotoxicology and Environmental Safety, 111:160-167 (2015) DOI: 10.1016/j.ecoenv.2014.09.008
  20. Watanabe KP, Kawai YK, Nakayama SMM, Ikenaka Y, Mizukawa H, Takaesu N, Ito M, Ikushiro S, Sakaki T, Ishizuka M. Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species. Journal of Veterinary Pharmacology and Therapeutics, 38(2):190-195 (2015) DOI: 10.1111/jvp.12159

▲このページの先頭へ

2014年

Original Articles

  1. Saengtienchai A, Ikenaka Y, Nakayama SMM, Mizukawa H, Kakehi M, Bortey-Sam N, Darwish W, Tsubota T, Terasaki M, Poapolathep A, Ishizuka M. Identification of inter-specific differences in phase II reactions: Determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene. Environmental Toxicology and Chemistry, 33(9):2062-2069 (2014) DOI: 10.1002/etc.2656
  2. Sutjarit S, Nakayama SMM, Ikenaka Y, Ishizuka M, Banlunara W, Rerkamnuaychoke W, Kumagai S, Poapolathep A. Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice. Toxicology Letters, 229: 292-302 (2014) DOI: 10.1016/j.toxlet.2014.06.843
  3. Ishii C, Ikenaka Y, Nakayama SMM, Suzuki Y, Watanuki Y, Watanabe Y, Yohannes YB, Mizukawa H, Ishizuka M. Contamination status and accumulation characteristics of metals and a metalloid in birds on Teuri Island, Hokkaido, Japan. The Japanese Journal of Veterinary Research, Volume 62, Number 3, 143-149 (2014) DOI: 10.14943/jjvr.62.3.143
  4. Fujisawa N, Nakayama SMM, Ikenaka Y, Ishizuka M. TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398. Arch. Toxicol, 88(9):1739-1748 (2014) DOI: 10.1007/s00204-014-1225-7
  5. Bortey-Sam N, Ikenaka Y, Nakayama SMM, Akoto O, Yohannes YB, Baidoo E, Mizukawa H, Ishizuka M. Occurrence, distribution, sources and toxic potential of polycyclic aromatic hydrocarbons (PAHs) in surface soils from the Kumasi Metropolis, Ghana. Sci Total Environ, 496:471-478 (2014) DOI: 10.1016/j.scitotenv.2014.07.071
  6. Mizukawa H, Ikenaka Y, Nakayama SMM, Sakamoto KQ, Fujita S, Ishizuka M. Contamination status and possibility of toxic effects of co-planar polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dichlorodiphenyltrichloroethane in large Japanese field mouse (Apodemus speciosus) collected from Hokkaido and Aomori. The Japanese Journal of Veterinary Research. Volume 62, Number 3, 107-115 (2014) DOI: 10.14943/jjvr.62.3.107
  7. Yohannes YB, Ikenaka Y, Nakamyama SMM, Ishizuka M. Organochlorine pesticides in bird species and their prey (fish) from the Ethiopian Rift Valley region, Ethiopia. Environmental Pollution 192:121-128 (2014) DOI: 10.1016/j.envpol.2014.05.007
  8. Yohannes YB, Ikenaka Y, Saengtienchai A, Watanabe KP, Nakamyama SMM, Ishizuka M. Concentrations and human health risk assessment of organochlorine pesticides in edible fish species from a Rift Valley Lake – Lake Ziway, Ethiopia. Ecotoxicol. Environ. Saf. 106:95-101 (2014) DOI: 10.1016/j.ecoenv.2014.04.014
  9. Yasui H, Takeuchi R, Nagane M, Meike S, Nakamura Y, Yamamori T, Ikenaka Y, Kon Y, Murotani H, Oishi M, Nagasaki Y, Inanami O. Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles. Cancer Letters 347:151-158 (2014) DOI: 10.1016/j.canlet.2014.02.005
  10. Akoto O, Bortey-Sam N, Nakayama SMM, Ikenaka Y, Baidoo E, Yohannes YB, Mizukawa H, Ishizuka M. Distribution of heavy metals in organs of sheep and goat reared in Obuasi: A gold mining town in Ghana. Int. J. Environ. Sci. Toxic. 2:81-89 (2014)
  11. M’kandawire E, Syakalima M, Muzandu K, Pandey G, Simuunza M, Nakayama SMM, Kawai YK, Ikenaka Y, Ishizuka M. Molecular characterization and mRNA expression of cytochrome P450 1A1 and cytochrome P450 3A in liver of Kafue Lechwe (Kobus leche kafuensis) as potential biomarkers of pollution of the Kafue River basin, Zambia. Engineering 6:51-58 (2014) DOI: 10.4236/eng.2014.62008
  12. Darwish WS, Ikenaka Y, Nakayama SMM, Ishizuka M. The effect of copper on the mRNA expression profile of xenobiotic-metabolizing enzymes in cultured rat H4-II-E cells. Biol. Trace Elem. Res. 158:243-248 (2014) DOI: 10.1007/s12011-014-9915-9
  13. Darwish WS, Ikenaka Y, Nakayama SMM, Ishizuka M. An overview on mycotoxin contamination of foods in Africa. J. Vet. Med. Sci. 76:789-797 (2014) DOI: 10.1292/jvms.13-0563
  14. Saengtienchai T, Poapolathep S, Isariyodom S, Ikenaka Y, Ishizuka M, Poapolathep A. Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets. Food Chem Toxicol. 66C:307-312 (2014) DOI: 10.1016/j.fct.2014.01.053
  15. Shimamoto Y, Watanabe K, Ikadai H, Okamura M, Ishizuka M. Repression of hepatic cytochrome P450 2D expression in mice during Babesia microti infection. J. Vet. Med. Sci. 76(8):1147-1151 (2014) DOI: 10.1292/jvms.14-0109

▲このページの先頭へ

2013年

Original Articles

  1. Ibrahim ZS, Ahmed MM, Shukry M, Mahmoud S, Ishizuka M. Constitutive androstane receptor dependent and independent modulation of CYP3A2, CYP1A2 by phenobarbital and fibrate in rats’ liver. Am. J. Biochem. Biotech 9:272-281(2013) DOI: 10.3844/ajbbsp.2013.272.281
  2. Kitamura H, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, Miyoshi I. Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. FASEB J. 27(12):4940-4953 (2013) DOI: 10.1096/fj.13-233528
  3. Watanabe KP, Kawai YK, Ikenaka Y, Kawata M, Ikushiro S, Sakaki T, Ishizuka M. Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver. PLOS ONE e75689(2013) DOI: 10.1371/journal.pone.0075689
  4. Fujisawa N, Kawai YK, Nakayama SMM, Ikenaka Y, Yamamoto H, Ishizuka M. Dioxin sensitivity-related two critical amino acids of arylhydrocarbon receptor may not correlate with the taxonomy or phylogeny in avian species. J Vet Med Sci 75:1577-1583 (2013) DOI: 10.1292/jvms.13-0179
  5. Sasaki N, Matumoto T, Ikenaka Y, Nakayama SMM, Ishizuka M, Kazusaka A, Fujita S. Repeated treatment with furazolidone induces multiple cytochrome P450-related activities in chicken liver but not in rat liver. J Vet Med Sci 75:1497-1502 (2013) DOI: 10.1292/jvms.12-0531
  6. Shimamoto Y, Kitamura H, Niimi K, Yoshikawa Y, Hoshi F, Ishizuka M, Takahashi E. Selection of suitable reference genes for mRNA quantification studies using common marmoset tissues. Molecular Biology Reports 40(12):6747-6755 (2013) DOI: 10.1007/s11033-013-2791-0
  7. Ikenaka Y, Oguri M, Saengtienchai A, Nakayama SMM, Ijiri S, Ishizuka M. Characterization of Phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: unique pyrene metabolism and species specificity observed in fish species. Environmental Toxicology and Pharmacology 36:567-578 (2013) DOI: 10.1016/j.etap.2013.05.018
  8. Kawai YK, Watanabe KP, Ishii A, Onuma A, Sawa H, Ikenaka Y, Ishizuka M. De novo sequence analysis of cytochrome P450 1–3 genes expressed in ostrich liver with highest expression of CYP2G19. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 8(3):201-208 (2013) DOI: 10.1016/j.cbd.2013.05.002
  9. Yohannes YB, Ikenaka Y, Saengtienchai A, Watanabe KP, Nakamyama SMM, Ishizuka M. Occurrence, distribution and ecological risk assessment of DDTs and heavy metals in surface sediments from Lake Awassa – Ethiopian Rift Valley Lake. Environ Sci Pollut Res 20:8663–8671 (2013) DOI: 10.1007/s11356-013-1821-8
  10. Fujisawa N, Darwish WS , Ikenaka Y, Kim E, Lee J,Iwata H, Nakayama SMM, Ishizuka M. Molecular evaluation of a new highly sensitive aryl hydrocarbon receptor in ostriches. Poultry Science  92(7):1921-1929 (2013) DOI: 10.3382/ps.2013-03090
  11. Yared BY, Ikenaka Y, Nakayama SMM, Saengtienchai A, Watanabe K, Ishizuka M, Organochlorine pesticides and heavy metals in fish from Lake Awassa; Ethiopia: Insights from stable isotope analysis. Chemosphere 91:857-863 (2013) DOI: 10.1016/j.chemosphere.2013.01.047
  12. Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Yabe J, Umemura T, Ishizuka M. Accumulation and biological effects of metals in wild rats in mining areas of Zambia. Environmental Monitoring and Assessment 185:4907-4918 (2013) DOI: 10.1007/s10661-012-2912-6
  13. Tanaka KD, Kawai YK, Ikenaka Y, Harunari T, Tanikawa T, Fujita S, Ishizuka M. A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats. J Vet Med Sci. 75(2):135-139 (2013) DOI: 10.1292/jvms.12-0161
  14. Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Choongo K, Mainda G, Kabeta N, Ishizuka M, Umemura T. Metal distribution in tissues of free-range chickens near a lead-zinc mine in Kabwe, Zambia. Environ Toxicol Chem. 32(1):189-192 (2013) DOI: 10.1002/etc.2029
  15. Nakayama SMM*, Ikenaka Y*, Muzandu K, Choongo K, Yabe J, Muroya T, Ijiri S, Minagawa M, Umemura T, Ishizuka M. GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis spp. from both field and laboratory studies. Arch Environ Contam Toxicol. 64(1):119-129 (2013) (* equal contribution) DOI: 10.1007/s00244-012-9802-3
  16. Ikenaka Y, Sakamoto M, Nagata T, Takahashi H, Miyabara Y, Hanazato T, Ishizuka M, Isobe T, Kim JW, Chang KH. Effects of polycyclic aromatic hydrocarbons (PAHs) on an aquatic ecosystem: acute toxicity and community-level toxic impact tests of benzo[a]pyrene using lake zooplankton community. J. Toxicol. Sci. 38(1):131-136 (2013) DOI: 10.2131/jts.38.131

Others

  1. Nakayama S.M.M, Ikenaka Y, Muzandu K, Choongo K, Yabe J, Umemura T, Ishizuka M. Metal contaminated soil from mining area caused metal accumulation and biological responses in rats. JJVR, 61:S77-S79 (2013)
  2. Hayami A, Darwish W.S, Ikenaka Y, Nakayama S.M.M, Ishizuka M. In vitro diazepam metabolism in horses. JJVR, 61:S80-S82 (2013)
  3. Darwish W.S, Eldaly E.A, EL-Abbasy M.T, Ikenaka Y, Nakayama S.M.M, Ishizuka M. Antibiotic residues in food: the African scenario. JJVR, 61:S1-S10 (2013)
  4. Darwish W.S, Ikenaka Y, Ishizuka M. Biological responses of xenobiotics metabolizing enzymes to lead exposure in cultured H4IIE rat cells. JJVR, 61:S48-S53 (2013)
  5. Oroszlany B, Ikenaka Y, Saengtienchai A, Oguri M, Nakayama S.M.M, Ishizuka M. Metabolism of pyrene, a polycyclic aromatic hydrocarbon in freshwater turtles. JJVR, 61:S62-S63 (2013)
  6. Bortey-Sam N, Akoto O, Ikenaka Y, Nakayama S.M.M, Ishizuka M. Determination of benzo[a]pyrene levels in ambient air and the source of polycyclic aromatic hydrocarbons using a diagnostic ratio method in Ghana. JJVR, 61:S64-S66 (2013)
  7. Ishii C, Ikenaka Y, Nakayama S.M.M, Suzuki Y, Watanuki Y, Watanabe Y, Fukuwaka M, Yohannes Y.B, Kawai Y.K, Ishizuka M. Heavy metal pollution in Japanese seabirds. JJVR, 61:S67-S69 (2013)
  8. Marfo J.T, Akoto O, Nakayama S.M.M, Baidoo E, Ikenaka Y, Ishizuka M. Distribution of metals in organs of Clarias gariepinus, Heterobranchus bidorsalis, and Chrysichthys nigrodigitatus from the Offin River at Dunkwa-on-Offin, Ghana. JJVR, 61:S70-S72 (2013)
  9. Mahmoud A.F.A, Darwish W.S, Morshdy A.E.M.A, Eldaly E.A, Ikenaka Y, Ishizuka M. Determination of organochlorine pesticides (OCPs) in the edible offal of Egyptian buffalo. JJVR, 61:S58-S63 (2013)

▲このページの先頭へ

2012年

Original Articles

  1. Mureithi D, Darwish WS, Ikenaka Y, Kanja L, Ishizuka M. Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts. Jpn. J. Vet. Res. 60(4):205-10(2012) DOI: 10.14943/jjvr.60.4.205
  2. Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T. Accumulation of metals in the liver and kidneys of cattle from agricultural areas in Lusaka, Zambia. J Vet Med Sci. 74(10):1345-7(2012) DOI: 10.1292/jvms.12-0142
  3. M’kandawire E, Syakalima M, Muzandu K, Pandey G, Simuunza M, Nakayama SMM, Kawai YK, Ikenaka Y, Ishizuka M. The nucleotide sequence of metallothioneins (MT) in liver of the Kafue lechwe (Kobus leche kafuensis) and their potential as biomarkers of heavy metal pollution of the Kafue River. Gene. 506(2):310-6(2012) DOI: 10.1016/j.gene.2012.07.002
  4. Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M. Effects of environmental lead contamination on cattle in a lead/zinc mining area: changes in cattle immune systems on exposure to lead in vivo and in vitro. Environ Toxicol Chem. 31(10):2300-5(2012) DOI: 10.1002/etc.1951
  5. Okagawa T, Konnai S, Mekata H, Githaka N, Suzuki S, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K. Transcriptional profiling of inflammatory cytokine genes in African buffaloes (Syncerus caffer) infected with Theileria parva. Vet Immunol Immunopathol. 148(3-4):373-9(2012) DOI: 10.1016/j.vetimm.2012.06.015
  6. Tanaka KD, Kawai Y, Ikenaka Y, Harunari T, Tanikawa T, Ando S, Min HW, Okajima F, Fujita S, Ishizuka M. The genetic mechanisms of warfarin resistance in Rattus rattus found in the wild in Japan. Pestic Biochem Physiol. 103(2)144-151 DOI: 10.1016/j.pestbp.2012.04.011
  7. Nakayama SMM, Ikenaka Y, Muzandu K, Choongo K, M’kandawire E, Yasuda J, Ishizuka M. Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia. Ecotoxicol Environ Saf. 80:333-8(2012) DOI: 10.1016/j.ecoenv.2012.04.003
  8. Suzuki S, Konnai S, Okagawa T, Githaka NW, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K. Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer). Int J Immunogenet. 39(2):170-82(2012) DOI: 10.1111/j.1744-313X.2011.01062.x
  9. Uno T, Ishizuka M, Itakura T. Cytochrome P450 (CYP) in fish. Environ Toxicol Pharmacol. 34(1):1-13(2012) DOI: 10.1016/j.etap.2012.02.004
  10. Kawamoto K, Otsuguro K, Ishizuka M, Ito S. Inhibitory effects of dopamine on spinal synaptic transmission via D1-like receptors in neonatal rats. Br J Pharmacol. 166(2):788-800(2012) DOI: 10.1111/j.1476-5381.2011.01815.x
  11. Shimamoto Y, Sasaki M, Ikadai H, Ishizuka M, Yokoyama N, Igarashi I, Hoshi F, Kitamura H. Down-Regulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti. J Vet Med Sci. 74(2):241-5(2012) DOI: 10.1292/jvms.11-0036
  12. Ohno M, Ikenaka Y, Ishizuka M. All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells. Biochem Biophys Res Commun. 417:484–489(2012) DOI: 10.1016/j.bbrc.2011.11.146
  13. Ohno M, Ikenaka Y, Ishizuka M. Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells. J Biochem Mol Toxicol. 26(1):16-22(2012) DOI: 10.1002/jbt.20408
  14. Fujisawa N, Ikenaka Y, Kim EY, Lee JS, Iwata H, Ishizuka M. Molecular Evidence Predicts Aryl Hydrocarbon Receptor Ligand Insensitivity in the Peregrine Falcon (Falco peregrines). Eur. J. Wildlife. Res. 58:167–175(2012)

Others

  1. Tanikawa T, Ishizuka M. Urban environment and commensal rodent. Urban Pest Management. 2(2):141-147(2012)

▲このページの先頭へ

2011年

Original Articles

  1. 池中良徳、石塚真由美. 野生動物の化学物質感受性と生体防御機構. 安全工学50(2): 80
  2. Ueda H, Ikenaka Y, Nakayama SM, Tanaka-Ueno T, Ishizuka M. Phase-II conjugation ability for PAH metabolism in amphibians: Characteristics and inter-species differences. Aquat Toxicol. 105(3-4):337-343(2011) DOI: 10.1016/j.aquatox.2011.07.004
  3. Saengtienchai A, Ikenaka Y, Watanabe K, Ishida T, Ishizuka M. Comparative Metabolism of Warfarin in Rats and Chickens. Poult Sci. 90:2775-2781(2011) DOI: 10.3382/ps.2010-01257
  4. Ohno M, Darwish WS, Ikenaka Y, Miki W, Fujita S, Ishizuka M. Astaxanthin rich crude extract of Haematococcus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cells. Food Chem. 130:356-361(2011) DOI: 10.1016/j.foodchem.2011.07.050
  5. Ohno M, Ikenaka Y, Ishizuka M. Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells. J Biochem Mol Toxicol. 26(1):16-22(2012) DOI: 10.1002/jbt.20408
  6. Yabe J, Nakayama SM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T. Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia. Environ Toxicol Chem. 30(8):1892-7(2011) DOI: 10.1002/etc.580
  7. Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M. Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia.Environmental Pollution 159 175-81(2011)
  8. Sasaki N, Matsumoto T, Ikenaka Y, Kazusaka A, Ishizuka M, Fujita S. Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens. Pestic.Biochem. Physiol., 100: 135-139(2011)
  9. Ohno M, Darwish WS, Miki W, Ikenaka Y, Ishizuka M. Astaxanthin can alter CYP1A-dependent activities via two different mechanisms: induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer. Food Chem Toxicol., 49: 1285-1291(2011)

▲このページの先頭へ

2010年

Original Articles

  1. Ikenaka Y, Nakayama SMM, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M. Heavy metal contamination of soil and sediment in Zambia. African Journal of Environmental Science and Technology 4(11):729-739. DOI: 10.4314/ajest.v4i11.71339
  2. Darwish WS, Ikenaka Y, Ohno M, Eldaly E. A, Ishizuka M. Carotenoids as regulators for inter-species difference in Cytochrome P450 1A expression and activity in ungulates and rats. Food and Chemical Toxicology. 48: 3201-8. DOI: 10.1016/j.fct.2010.08.022
  3. Chang HS, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O. Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. Nutr. Res., 30: 435-440. DOI: 10.1016/j.nutres.2010.06.007
  4. Darwish WS, Ikenaka Y, Eldaly E. A, Ishizuka M. Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animals. Food Chem. Toxicol., 48: 2526-2531. DOI: 10.1016/j.fct.2010.06.026
  5. Yabe J, Ishizuka M, Umemura T. Current levels of heavy metal pollution in Africa. J Vet Med Sci. 2010 Oct;72(10):1257-63. DOI: 10.1292/jvms.10-0058
  6. Darwish WS, Ikenaka Y, El-Ghareeb WR, Ishizuka M. High expression of the mRNA of cytochrome P450 and phase II enzymes in the lung and kidney tissues of cattle. Animal 4(12):2023-2029(2010) DOI: 10.1017/S1751731110001394
  7. Kawai YK, Ikenaka Y, Fujita S, Ishizuka M. The CYP1D subfamily of genes in mammals and other vertebrates. Mamm Genome. 21(5-6):320-9(2010) DOI: 10.1007/s00335-010-9263-9
  8. Darwish WS, Kawai Y, Ikenaka Y, Yamamoto H, Muroya T, Ishizuka M. Identification and phylogenetic analysis of novel cytochrome P450 1A genes from ungulate species. J Vet Med Sci. 72(9):1237-1241(2010) DOI: 10.1292/jvms.10-0019
  9. Watanabe KP, Saengtienchai A, Tanaka KD, Ikenaka Y, Ishizuka M. Comparison of warfarin sensitivity between rat and bird species. Comp Biochem Physiol C Toxicol Pharmacol. 152(1):114-9(2010) DOI: 10.1016/j.cbpc.2010.03.006
  10. Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M. Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue. Toxicol. Sci. 116(1):79-91(2010) DOI: 10.1093/toxsci/kfq087
  11. Nakayama MMS, Ikenaka Y, Muzandu K, Choongo K, Oroszlany B, Teraoka H, Mizuno N, Ishizuka M. Heavy metal accumulation in lake sediments, fish (Oreochromis niloticus and Serranochromis thumbergi) and crayfish (Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia. Arch Environ Contam Toxicol. 59(2):291-300(2010) DOI: 10.1007/s00244-010-9483-8
  12. Darwish WS, Ikenaka Y, Eldaly EA, Ohno M, Sakamoto KQ, Fujita S, Ishizuka M. Cytochrome P450 1A dependent activities in deer, cattle, and horses. J Vet Med Sci. 72(5):561-6(2010) DOI: 10.1292/jvms.09-0318
  13. Sata F. Kurahashi N. Ban S. Moriya K. Tanaka KD. Ishizuka M. Nakao H. Yahata Y. Imai H. Kakizaki H. Nonomura K. Kishi R. Genetic polymorphisms of 17β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias. J. Sex. Med. 7: 2729-2738 DOI: 10.1111/j.1743-6109.2009.01641.x
  14. Darwish WS, Morshdy AE, Ikenaka Y, Ibrahim ZS, Fujita S, Ishizuka M. Expression and Sequence of CYP1A in Camel. J Vet Med Sci. 72(2):221-4(2010) DOI: 10.1292/jvms.09-0319
  15. Kim HS, Sakai N, Saito K, Fujita S, Ishizuka M. Diazepam metabolism in kidney of male and female rats of varying strain. J Vet Med Sci. 72(1):7-11(2010) DOI: 10.1292/jvms.09-0127
  16. Sakamoto QK, Sato K, Kato A, Fukui D, Bando G, Naito Y, Habara Y, Ishizuka M, Fujita S. Metabolic alkalosis due to feeding chicks in breeding Adélie penguins Pygoscelis adeliae under natural conditions. Physiological and Biochemical Zoology. 83(2):232-238(2010) DOI: 10.1086/597517

▲このページの先頭へ

2009年

Original Articles

  1. Tanaka K, Harunari T, Tanikawa T, Ikenaka Y, Ishizuka M. Warfarin-resistant of rats in Japan. Jpn. J. Environ. Toxicol. 12(2):61-70(2009) DOI: 10.11403/jset.12.61
  2. Sakai N, IshizukaM. Impact of rat P450 genetic polymorphism on diazepam metabolism. Expert Opinion On Drug Metabolism and Toxicology. 5(11):1421-33(2009) DOI: 10.1517/17425250903207002
  3. El Bohi KM, Hashimoto Y, Muzandu K, Ikenaka Y, Ibrahim ZS, Kazusaka A, Fujita S, Ishizuka M. Protective effect of Pleurotus cornucopiae mushroom on carbon tetrachloride-induced hepatotoxicity. Jpn J Vet Res. 57(2):109-18(2009)
  4. Nakayama SMM, Tanaka-Ueno T, Sakamoto QK, Fujita S, Ishizuka M. Molecular cloning of novel cytochrome P450 1A genes from nine Japanese amphibian species. J Vet Med Sci. 71(10):1407-11(2009) DOI: 10.1292/jvms.001407
  5. Sakai N, Sakamoto KQ, Fujita S, Ishizuka M. The importance of heterogeneous nuclear ribonucleoprotein K on Cytochrome P450 2D2 gene regulation: its binding is reduced in Dark Agouti rats. Drug Metab Dispos. 37(8):1703-10(2009) DOI: 10.1124/dmd.109.027284
  6. Sakamoto KQ, Sato K, Ishizuka M, Watanuki Y, Takahashi A, Daunt F, Wanless S. Can ethogram be automatically generated using bodyacceleration data from free-ranging birds? PLoS ONE. 4(4):e5379(2009) DOI: 10.1371/journal.pone.0005379
  7. Ohno M, Sakamoto KQ, Ishizuka M, Fujita S. Crude cacao Theobroma cacao extract reduces mutagenicity induced by benzo[a]pyrene through inhibition of CYP1A activity in vitro. Phytotherapy Research. 23(8):1134-9(2009) DOI: 10.1002/ptr.2762
  8. Sakai N, Saito K, Sakamoto QK, Ishizuka M, Fujita S. Genetic bases basis of inter- and intra-strain differences in diazepam p-hydroxylation in rats. Drug Metab Dispos. 37(2):268-71(2009) DOI: 10.1124/dmd.108.024273
  9. Nakano K, Ishizuka M, Sakamoto QK, Fujita S Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate. Biometals 22(2):345-51(2009) DOI: 10.1007/s10534-008-9171-6
  10. Sakamoto QK, Sato K, Naito Y, Habara Y, Ishizuka M, Fujita S. Morphological features and blood parameters of Weddell seal (Leptonychotes weddellii) mother and pup during breeding season. J Vet Med Sci. Mar;71(3):341-4(2009) DOI:

▲このページの先頭へ

2008年

Original Articles

  1. Rahman MH, Sakamoto KQ, Nonaka L, Suzuki S. Occurrence anddiversity of
    tetracycline resistance gene tet(M) in enteric bacteria of Antarctic Adélie penguin.
    J Antimicrob Chemother. 62(3):627-8(2008)
  2. Ibrahim SZ, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy MA, Sakamoto QK, Fujita S. Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 56(3):119-28(2008)
  3. Moustafa GG, Ibrahim ZS, Ahmed MM, Ghoneim MH, Sakamoto KQ, *Ishizuka M, Fujita S. Downregulation of male-specific cytochrome P450 by profenofos. Jpn J Vet Res. 56(2):109-18(2008)
  4. Ishizuka M, Tanikawa T, Tanaka KD, Heewon M, Okajima F, Sakamoto KQ, Fujita S. Pesticide resistance in wild mammals–mechanisms of anticoagulant resistance in wild rodents. J Toxicol Sci. 33(3):283-91(2008)
  5. Ishizuka M, Fujioka K, Shibamoto T. Analysis of acrylamide in a complex matrix of polyacrylamide solutions treated by heat and ultraviolet light. J Agric Food Chem. 56(15):6093-6(2008)
  6. Refat NA, Ibrahim ZS, Moustafa GG, Sakamoto KQ, *Ishizuka M, Fujita S.
    The induction of cytochrome P450 1A1 by sudan dyes. J Biochem Mol Toxicol. 22(2):77-84(2008)
  7. Sasaki N, Sakai N, Ikenaka Y, Kamiya T, Heewon M, Sakamoto KQ, *Ishizuka M, Fujita S.
    Antibiotic furazolidone induces CYP1A but not CYP2E1 subfamily in rat liver. J Vet Med Sci. 70(3):223-6(2008)
  8. Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R.
    Adverse birth outcomes associated with maternal smoking and polymorphisms
    in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1.Am J Epidemiol. 167(6):719-26(2008)

▲このページの先頭へ

2007年

Original Articles

  1. Ban S, Kondo T, Ishizuka M, Sasaki S, Konishi K, Washino N, Fujita S, Kishi R. Using microarray analysis to evaluate genetic polymorphisms involved in the metabolism of environmental chemicals. Fukuoka Igaku Zasshi. 98(5):208-14(2007)
  2. Kim HS, Ishizuka M, Kazusaka A, Fujita S. Di-(2-ethylhexyl)phthalate suppresses tamoxifen-induced apoptosis in GH3 pituitary cells. Arch. Toxicol. 81:27-33(2007)
  3. Moustafa GG, Ibrahim ZS, Hashimoto Y, Alkelch AM, Sakamoto KQ, Ishizuka M, Fujita S.
    Testicular toxicity of profenofos in matured male rats. Arch Toxicol. 81(12):875-81(2007)
  4. Ishizuka M, Okajima F, Tanikawa T, Min H, Tanaka KD, Sakamoto KQ, Fujita S. Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo. Drug Metab Dispos. 35(1):62-6(2007)
  5. Ishizuka M, Nagai S, Sakamoto KQ, Fujita S. Plasma pharmacokinetics and CYP3A12-dependent metabolism of c-kit inhibitor imatinib in dogs. Xenobiotica. 37(5):503-13(2007)
  6. Sasaki S, Kondo T, Sata F, Saijo Y, Katoh S, Nakajima S, Ishizuka M, Fujita S and Kishi R.
    Maternal smoking during pregnancy and genetic polymnobiotica. 37(5):503-13(2007)

▲このページの先頭へ

2006年

Original Articles

  1. Jinno A, Maruyama Y, Ishizuka M, Kazusaka A, Nakamura A, and Fujita S. Induction of cytochrome P450‐1A by the equine estrogen equilenin, a new endogenous aryl hydrocarbon receptor ligand. J. Steroid. Biochem. Mol Biol . , 98:48‐55(2006)
  2. Ishizuka M, Lee JJ, Masuda M, Akahori F, Kazusaka A, and Fujita S. CYP2D-related metabolism in animals of the Canoidea superfamily-species differences. Vet. Res. Commun.,30:505‐512(2006)
  3. Sasaki S, Kondo T, Sata F, Saijo Y, Katoh S, Nakajima S, Ishizuka M, Fujita S, and Kishi R.

    Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP1A1 and GSTM1 affect infant birth size inJapanese subjects. Mol. Hum. Reprod., 12:77‐83(2006)

  4. Tanikawa T, Ishizuka M, and Fujita S. Effectiveness of difethialone baits to warfarin-resistant and susceptible colonies on roof rats, Rattus rattus. Medical Entomology and Zoology.,57:355‐359(2006)
  5. Muzandu K, Ishizuka M, Sakamoto K Q, Shaban Z, El Bohi K, Kazusaka A, and Fujita S. Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications . Toxicol . Appl . Pharmacol.,215:330‐340(2006)

▲このページの先頭へ

2005年

Original Articles

  1. Sakai N, Saito K, Kim HS, Kazusaka A, Ishizuka M, Funae Y, and Fujita S.
    Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats. Drug Metab, Dispos.,33(11):1657 ‐60(2005)
  2. Muzandu K, Shaban Z, Ishizuka M, Kazusaka A, and Fujita S.
    Nitric oxide enhances catechol estrogen-induced oxidative stress in LNCaP cells . Free Radic Res.,39(4):389‐98(2005)
  3. Nikaidou S, Ishizuka M, Maeda Y, Hara Y, Kazusaka A, and Fujita S. Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens. Jpn. J. Vet. Res., 52(4):185‐92(2005)
  4. Muzandu K, El Bohi K, Shaban Z, Ishizuka M, Kazusaka A, and Fujita S. Lycopene and beta-carotene ameliorate catechol estrogen-mediated DNA damage. Jpn. J. Vet. Res.,52(4):173‐84(2005)
  5. El Bohi KM, Sabik L, Muzandu K, Shaban Z, Soliman M, Ishizuka M, Kazusaka A, and Fujita S.
    Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA98elicited by
    benzo [a]pyrene and oxidative DNA lesions in V79hamster lung cells . Jpn . J. Vet . Res.,52(4):163‐72(2005)
  6. Shaban Z, Soliman M, El-Shazly S, El-Bohi K, Abdelazeez A, Kehelo K, Kim H S, Muzandu K, Ishizuka M, Kazusaka A, and Fujita S. AhR and PPARalpha : antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11.Xenobiotica. ,35(1):51‐68(2005)
  7. Nikaidou S, Ishizuka M, Maeda Y, Hara Y, Kazusaka A, and Fujita S. Effect of catechins on mutagenesis of Salmonella typhimurium TA102 elicited by tert-butyl hydroperoxide(t-BuOOH).J. Vet. Med. Sci.,67(1):137‐8(2005)

▲このページの先頭へ

2004年

Original Articles

  1. Shaban Z, El-Shazly S, Abdelhady S, Fattouh I, Muzandu K, Ishizuka M, Kimura K, Kazusaka A, Fujita S. Down regulation of hepatic PPARalpha function by AhR ligand. J. Vet. Med. Sci. 66 :1377-1386(2004)
  2. Sakamoto KQ, Ishizuka M, Kazusaka A, Fujita S. Iodine intake as a possible cause of discontinuous decline in sperm counts: a re-evaluation of historical and geographic variation in semen quality. Jpn. J. Vet. Res. 52 : 85-94(2004)
  3. Kim HS, Ishizuka M, Kazusaka A, Fujita S. Alterations of activities of cytosolic phospholipase A2 and arachidonic acid-metabolizing enzymes in di-(2-ethylhexyl)phthalate-induced testicular atrophy. J. Vet. Med. Sci. 66 : 1119-1124(2004)
  4. Saito K, Sakai N, Kim HS, Ishizuka M, Kazusaka A, Fujita S. Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats. Drug Metab. Dispos. 32 : 959-65(2004)
  5. Shaban Z, El-Shazly S, Ishizuka M, Kimura K, Kazusaka A, Fujita S. PPARalpha-dependent modulation of hepatic CYP1A by clofibric acid in rats. Arch. Toxicol. 78 : 496-507(2004)
  6. Saito K, Kim HS, Sakai N, Ishizuka M, Kazusaka A, Fujita S. Polymorphism in diazepam metabolism in Wistar rats. J. Pharm. Sci. 93 : 1271-1278(2004)

▲このページの先頭へ

2003年

Original Articles

  1. Kim HS, Saito K, Ishizuka M, Kazusaka A, Fujita S. Short period exposure to di-(2-ethylhexyl) phthalate regulates testosterone metabolism in testis of prepubertal rats. Arch Toxicol., 77, 8 : 446-51(2003)
  2. Sakamoto KQ, Nakai K, Aoto T, Yokoyama A, Ushikoshi R, Hirose H, Ishizuka M, Kazusaka A, Fujita S. Cytochrome p450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan. Chemosphere. 51, 6 : 491-500(2003)
  3. Ishizuka M, Yonemoto J, Zaha H, Tohyama C, Sone H. Perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters sex-dependent expression of hepatic CYP2C11. J Biochem Mol Toxicol., 17, 5 : 278-85(2003)
  4. Hoshino H, Fujita S, Goto Y, Isono T, Tsuyoshi I, Yasunori S. Organochlorine compound accumulation in Steller sea lion Eumetopias jubatus migrating along the coast of Hokkaido in northern Japan.
    Jpn J Toxicol. 6, 1 : 1-10(2003)

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2002年

  1. Sakamoto KQ, Nakai K, Aoto T, Yokoyama A, Ushikoshi R, Hirose H, Ishizuka M, Kazusaka A, Fujita S. Cytochrome P450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan. Chemosphere. 51(6):491-500(2003)
  2. Tilley RE, Kemp GD, Teramitsu I, Hall AJ. Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus). Comp Biochem Physiol C Toxicol Pharmacol. 132(2) 181-191(2002)
  3. Sakamoto KQ, Kunisue T, Watanabe M, Masuda Y, Iwata H, Tanabe S, Akahori F, Ishizuka M, Kazusaka A, Fujita S. Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller’s sea eagles and white-tailed sea eagles, threatened species, in Hokkaido, Japan. Environ Toxicol Chem. 21(4):842-7(2002)
  4. Chiba I, Sakakibara A, Iwata TH, Ishizuka M, Tanabe S, Akahori F, Kazusaka A, Fujita S. Hepatic microsomal cytochrome p450s and chlorinated hydrocarbons in largha and ribbon seals from Hokkaido, Japan: differential response of seal species to Ah receptor agonist exposure. Environ Toxicol Chem. 21(4):794-806(2002)
  5. 石塚真由美、藤田正一 「化学物質による野生生物及び生態系への影響とは」化学物質と環境 58:7-10(2003)

Publications other than original articles

  1. 石塚真由美、岩田久人、藤田正一:トキシコロジー7章 環境毒性(日本トキシコロジー学会)(290-303)(2002)
  2. 板倉隆夫、石塚真由美、藤田正一:シトクロムP450(講談社サイエンティフィク)
  3. 藤田正一「臨床薬物代謝化学」(廣川書店)
  4. Ishizuka M. Yamamoto Y. Takada A. Kazusaka A. Fujita S. The loss of enzyme activities by a single amino acid substitution of a newly cloned rabbit CYP2D isozyme, CYP2D24. International Congress Series. 1223:121-126(2002)

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2001年

Original Articles

  1. Sakamoto QK, Kunise T, Watanabe M, Masuda Y, Iwata H, Tanabe S, Akahori F, Ishizuka M, Kazusaka A, Fujita S. Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller’s sea eagles and White-tailed sea eagles, threatened species, in Hokkaido, Japan. Environ Toxicol Chem. 21(4):842-7(2002)
  2. Chiba I, Sakakibara A, Iwata H, Ishizuka M, Tanabe S, Kazusaka A, Fujita S. Hepatic microsomal cytochrome P450s and chlorinated hydrocarbons in largha and ribbon seals from Hokkaido, Japan: Differential response of seal species to Ah receptor agonist exposure. Environ Toxicol Chem. Apr;21(4):794-806(2002)
  3. Maruyama Y, Suzuki Y, Kazusaka A, Fujita S. Uptake of the dopaminergic neurotoxin, norsalsolonol, into PC12 cells via dopamine transpoter. Archives of toxicology. 75(4):209-13(2001)
  4. Teraoka H, Maruyama Y, Takehana K, Iwanaga T, Hiraga T, Fujita S, Ohta T. Ca(2+) signaling in porcine duodenal glands by muscarinic receptor activation. Am J Physiol Gastrointest Liver Physiol. 280(4):G729-37(2001)
  5. Maruyama Y, Suzuki Y, Kazusaka A, Fujita S. Norsalsolinol uptake into secretory vesicles via vesicular monoamine transporter and its secretion by membrane depolarization or purinoceptor stimulation in PC12 cells. J Vet Med Sci. 63(5):493-7(2001)
  6. Chiba I, Sakakibara A, Goto Y, Isono T, Yamamoto Y, Iwata H, Tanabe S, Shimazaki K, Akahori F, Kazusaka A, Fujita S. Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seal from the coast of Hokkaido, Japan.? Environ Toxicol Chem. 20(5):1092-7(2001)
  7. Fujita S, Chiba I, Ishizuka M, Hoshi H, Iwata H, Sakakibara A, Tanabe S, Kazusaka A, Masuda M, Masuda Y, Nakagawa H. P450 in wild animals as biomarker of environmental impact. Biomarkers 6(1):13-25(2001)
  8. Yamamoto H, Watanabe T, Mizuno H, Endo K, Fukushige J, Hosokawa T, Kazusaka A, Fujita S. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 34(1):69-80(2001)
  9. Yamamoto H, Watanabe T, Mizuno H, Endo K, Hosokawa T, Kazusaka A, Gooneratne R, Fujita S. In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. Free Radic Biol Med. 30(5):547-54(2001)
  10. Maruyama Y, Teraoka H, Iwata H, Kazusaka A, Fujita S. Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochem Int. 38(7):567-572(2001)

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2000年

  1. Chiba I, Sakakibara A, Goto Y, Isono T, Yamamoto Y, Iwata H, Tanabe S, Shimazaki K, Akahori F, Kazusaka A,
    Fujita S. Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seal from the coast of Hokkaido, Japan.? (Environ Toxicol Chem. 20(5):1092-7(2001)
  2. Fujita S, Chiba I, Ishizuka M, Hoshi H, Iwata H, Sakakibara A, Tanabe S, Kazusaka A, Masuda M, Masuda Y, Nakagawa H. P450 in wild animals as biomarker of environmental impact. Biomarkers 6(1):13-25(2001)
  3. Teramitsu I, Yamamoto Y, Chiba I, Iwata H, Tanabe S, Fujise Y, Kazusaka A, Akahori F, Fujita S. Identification of novel cytochrome P450 1A genes from five marine mammal species. Aquat Toxicol. Dec 1;51(2):145-153(2000)
  4. Yamamoto H, Watanabe T, Mizuno H, Endo K, Fukushige J, Hosokawa T, Kazusaka A, Fujita S. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 34(1):69-80(2001)
  5. Yamamoto H, Watanabe T, Mizuno H, Endo K, Hosokawa T, Kazusaka A, Gooneratne R, Fujita S. In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. Free Radic Biol Med. 30(5):547-54(2001)
  6. Maruyama Y, Teraoka H, Iwata H, Kazusaka A, Fujita S. Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochem Int. 38(7):567-572(2001)
  7. Yoon S, Kazusaka A, Fujita S. FTIR spectroscopic and HPLC chromatographic studies of carbon tetrachloride induced acute hepatitis in rats: damage in liver phospholipid membrane. Biopolymers. 57(5):267-71(2000)
  8. Yoon S, Maruyama Y, Kazusaka A, Fujita S. Application of FT-IR and ESR spectroscopic techniques to the study of CCl4-induced peroxidation in rat liver microsomes. Jpn J Vet Res. Feb;47(3-4):151-4(2000)
  9. Yoon S, Maruyama Y, Kazusaka A, Fujita S. Accumulation of diacylglycerol induced by CCl4-derived radicals in rat liver membrane and its inhibition with radical trapping reagent–FT-IR spectroscopic and HPLC chromatographic observations. Jpn J Vet Res. 47(3-4):135-44(2000)

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1999年

Original Articles

  1. Nakamura A, Hirota T, Morino A, Imaoka ., Funae Y, Yamamota Y, Tasaki T, Masuda M, Kazusaka A, and Fujita S. Cylochrome P-450 isoforms responsible for the N-demethylation an d cyclohexane-hydroxylation of NS-21. Xenobiotica, 29 : 243-252(1999)
  2. Shimamoto Y, Tasaki T, Kitamura H, Hirose K, Kazusaka A, and Fujita S. Decrease in hepatic CYP 2 C11 mRNA and increase in heme oxygenase activity after intracerebroventricular injection of bacterial endotoxin. J. Vet. Med. Sci.,61 : 609-613(1999)
  3. Shimamoto Y, Kitamura H, Iwai M, Saito M, Kazusaka A, and Fujita S. Mechanism of decresae in levels of hepatic P450 isozymes induced by intracerebral endotoxin. Arch. Toxicol . , 73 : 41-49(1999)
  4. Yamamoto H, Hirose K, Hayasaki Y, Masuda M, Kazusaka A, and Fujita S. Mechanism of enhanced lipid peroxidation in the liver of Long-Evance cinnamon (LEC) rats. Arch. Toxicol., 73 : 457-464(1999)
  5. Kblood EBM, Miyoshi H, Iwata H, Kazusaka A, Kon Y, Handid AHA, Moustafe EK, Ghomin MH, and Fujita S. Effects of concurrent exposure to 3 -methylcholanthrene and vitamin A on fetal development in rats. Jpn. J. Vet. Res.,47 : 13-23(1999)
  6. Takahashi J, Furuhata Y, Ikeda A, Takahashi M, Iwata H, Kazusaka A, and Fujita S. Characterization of hepatic cyiochrome P450 isozyme composition in the transgenic rat expressing low level human growth hormone. Xenobiotica, 29 : 1203-1212(1999)
  7. Kim E-Y, Goto R, Iwata H, Masuda Y, Tanabe S, and Fujita S. Preliminary survey of, Iead poisoning of steller’s sea eagle ( Haliaeetus pelagicus) and White-tailed sea eagle (Haliaeetus albicilla) in Hokkaido, Japan. Environmental Toxicology and Chemistry, 18 : 448-451(1999)
  8. Fujita S. Experimental use of debate in a science class. J. Higher Education and Lifelong Learning, 5 : 74-91(1999, in Japanese with English Summary)

Publications other than original articles

  1. Yoon S, Kazusaka A, and Fujita S. Infrared spectroscopic study on the mechanism of CC14 toxicity toward membrane phospholipids from rat liver. J. Toxicol. Sci., 24, 370(1999)
  2. Maruyama Y, Suzuki Y, Teraoka H, lwata H, Kazusaka A, and Fujita S. Norsalsolinol, an endogeneous dopaminergic neurotoxin , inhibits dopamine secretion in PC12 cells. J. Toxicol. Sci., 24, 358(1999)
  3. Chiba I, Sakakibara A, Iwata H, Tanabe S, Kazusaka A, and Fujita S. Seal liver P450, as a marker enzyme for marine pollution. J. Toxicol. Sci., 24, 301(1999)
  4. Yoon S, Kazusaka A, and Fujita S. FT-IR observation of conformational change in the rat liver phosphol-ipid with spontaneous or chemical in-duced hepatitis. Fourier Transform Spectroscopy, 12th International Conference, pp475-476(1999)
  5. Sasaki I, Kawanabe A, Yamakawa I, Kazusaka A, Yoon S, and Fujita S. In vivo observation of cylochrome P450 1 A isozyme reaction in liver of living rats by using fiberoptic sensor. Proceedings of 13th international conference on optical fiber sensor, Seoul, Korea(1999)

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1998年

Original Articles

  1. Tasaki T, Nakamura A, Itoh S, Ohashi K, Yamamoto Y, Masuda M, Iwata H, Kazusaka A, Kamataki T, Fujita S. Expression and characterization of dog CYP2D15 using baculovirus expression system. J. Biochem. 123, 162-168 (1998)
  2. Ishizuka M, Sakiyama T, Iwata H, Fukushima M, Kazusaka A, Fujita S. Accumulation of halogenated aromatic hydrocarbons and activities of cytochrome P450 and glutathione S-transferase in crabs (Eriocheir japonicus) from Japanese rivers. Environmental Toxicology and Chemistry 17, 1490-1498 (1998)
  3. Yamamoto Y, Tasaki T, Nakamura A, Iwata H, Kazusaka A, Gonzalezb FJ, Fujita S. Molecular basis of the dark agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2. Pharmacologenetics 8, 73-82 (1998)
  4. Yamamoto Y, Ishizuka M, Takada A, Fujita S. Cloning, tissue distribution, functional expression of novel rabbit cytochrome P450 isozymes, CYP2D23 and CYP2D24. J. Biochem., 124, 503-508 (1998)
  5. Tasaki T, Iwata H, Kazusaka A, Fujita S. Regio- and stereoselectivity in propranolol metabolism by dog liver microsomes and dog CYP2D15. J. Biochem. 123, 747-751 (1998)
  6. Hoshi H, Minamoto N, Iwata H, Shiraki K, Tatsukawa R, Tanabe S, Fujita S, Hirai K, Kinjyo T. Organochlorine pesticides and polychlorinated biphenyl congeners in wild terrestrial mammals and birds from Chubu region, Japan: Interspecies comparison of the residue levels and compositions. Chemosphere, 36, 3211-3221 (1998)
  7. Ishizuka M, Iwata H, Hatakeyama S, Kazusaka A, Fujita S. Effects of the agrochemicals butachlor, pretiolachlor and isoprothiolaane on rat liver xenobioticmetabolizing enzymes. Xenobiotica, 11, 1029-1039 (1998)
  8. Morita K, Maeda Y, Masuda M, Kazusaka A, Fujita S. Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Biochem. Pharmacol., 55, 1405-1411 (1998)
  9. Iwata H, Tanabe S, Iida T, Baba N, Ludwig JP, and Tatsukawa R. Enantioselective accumulation of alpfa-hexachlorocyclohexane in northern furseals and double-crested cormorants: Effects of biological and ecological factors in the higher trophic levels. Environ. Sci. Technol., 32, 2244-2249 (1998)
  10. Shimamoto Y, Kitamura H, Hoshi H, Kazusaka A, Funae Y, Imaoka S, Saito M, Fujita S. Differential alteration of microsomal cytochrome P450 levels in rat liver microsomes following intracerebral injection of bacterial lipopolysaccharide. Archive of Toxicology, 72, 492-498 (1998)

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1997年

Original Articles

  1. Ishizuka M, Yoshino S, Yamamoto Y, Yamamoto H, Imaoka S, Funae Y, Iwata H, Masuda M, Kazusaka A, and Fujita S. Pathway-selective alteration of imipramine metabolism during regeneration of male rat liver following partial hepatectomy. Xenobiotica, 27 : 923-931(1997)
  2. Maeda Y, Morita K, Tasaki T, Masuda M, Kazusaka A, and Fujita S. Strain differences in testosterone metabolism in Wistar and Dark Agouti rats.-A new polymorphism-. Environ. Toxicol. Pharmacol., 3 : 1-6(1997)
  3. Maeda Y, Taira T, Haraguchi K, Hirose K, Kazusaka A, and Fujita S. Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. Cancer Lett., 119 : 137-141(1997)
  4. Iwata H, Tanabe S, Mizuno T, and Tatsukawa R. Bioaccumulation of butyltin compounds in marine mammals: Their tissue distribution and composition. Appl. Organomet. Chem., 11 : 257-264(1997)
  5. Guruge KS, Iwata H, Tanaka H, and Tanabe S. Accumulation of butyltins in the liver and kidney of seabirds. Mar. Environ. Res., 44 : 191-199(1997)
  6. Tasaki T, Nakamura A, Itoh S, Ohashi K, Yamamoto Y, Masuda M, Iwata H, Kazusaka A, Kamataki T, and Fujita S. Expression and characterization of dog CYP2D15 using baculovirus expression system. J. Biochem., 123 : 162-168(1998)
  7. Yamamoto Y, Tasaki T, Nakamura A, Iwata H, Kazusaka A, Gonzalez FJ, and Fujita S. Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Involvement of CYP2D1 and CYP2D2. Pharmacogenetics, 8 : 73-82(1998)

Publications other than original articles

  1. Fujita S. Current status of university entrance examination and its impact on the education. J. Higher Education (Hokkaido Univ.), 2 : 171-179(1997, in Japanese)
  2. Iwata H, Watanabe M, Tanabe S, Masuda Y, Masuda M, Kazusaka A, and Fujita S. High level of chlorinated hydrocarbons found in Stellars sea eagles found dead in Shiretoko Peninsula. Annual Report of Shiretoko Museum, 18 : 1-7(1997, in Japanese)
  3. Hoshi H. A method for monitoring environmental contamination-Environmental monitoring using wild rodent’s P450 as an indicator-. Jpn. J. Zoo Wild. Med., 2 : 9-12(1997, in Japanese)

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1996年

Original Articles

  1. Fujita S, Masuda M, Shimamoto Y, Hoshi H, Kariya S, Kazusaka A. and Suzuki T. Effect of 3-methylcholan-threne on bunitrolol metabolism: Kinetics and immunological studies on 4-hydroxylation of bunitrolol catalyzed by two species of cytochromes P450 in rat liver microsomes. Drug Metab. Dispos., 24: 254-259(1996)
  2. Ishizuka M, Hoshi H, Minamoto N, Masuda M, Kazusaka A. and Fujita S. Alterations of cytochrome P450 dependent monooxygenase activities in Eriocheir japonicus in response to water pollution. Environ. Health Persp., 104: 774-778(1996)
  3. Yamamoto Y, Nakamura A, Tasaki T, Umeda S, Sugimoto C, Imaoka S, Funae Y, Masuda M, Kazusaka A. and Fujita S. Impaired expression in DA rats of catalytically active P450BTL, immunochemically distinguishable from P4502D1: Immunological evidence with specific anti-peptide antibodies. Biomed. Res., 17: 331-337(1996)
  4. Hatakeyama S, Hayasaki Y, Masuda M, Kazusaka A. and Fujita S. Mechanism for mouse strain differences in the protective effect of Sudan III against the in vivo genotoxicity of 7, 12-dimethylbenz-(a)anthracene. Toxicol. Lett., 89: 231-239(1996)
  5. Tanabe S, Kummran P, Iwata H, Tatsukawa R. and Miyazaki N. Enantiomeric ratios of alpha-hexachlorocyclohexane in blubber of small cetaceans. Mar. Pollut. Bull., 32: 27-31(1996)
  6. Kim GB, Lee JS, Tanabe S, Iwata H, Tatsukawa R. and Shimazaki K. Specific accumulation of butyltin compounds in various organs and tissues of steller sea lion (Eumetopias jubatus): Comparison with organochlorine compounds. Mar. Pollut. Bull., 32: 558-563(1996)
  7. Guruge KS, Tanabe S, Iwata H, Tatsukawa R. and Yamagishi S. Distribution, biomagnification, and elimination of butyltin compound residues in common cormorant (Phalacrocorax carbo) from Lake Biwa, Japan. Arch. Environ. Contam. Toxicol., 31: 210-217(1996)

Publications other than original articles

  1. Fujita S. Inhibition of cytochrome P450. Jpn. J. Toxicol., 9: 149-158 (1996, in Japanese).
  2. Fujita S. Opinions of the teaching staff of Hokkaido university on the evaluation of their lectures by students. J. Higher Education (Hokkaido Univ.), 1: 81-104 (1996, in Japanese).
  3. Fujita S. Students’ evaluation of the lectures of Hokkaido university. Tsukuba Forum, 45: 28-34 (1996, in Japanese).
  4. Kazusaka A. Thinking about environmental science. J. Environmental Protection Center of Hokkaido University, 5: 9-12 (1996, in Japanese).
  5. Kazusaka A. One biological reaction occurred by copper ions. Shokubai, 38: 316-317 (1996, in Japanese).
  6. Iwata H. and Tatsukawa, R. Marine pollution by organochlorines. In: Civilization and Environment: Environmental Crisis and Modern Civilization, pp. 114-129, Ishi, H. and Numata, S. eds., Asakura Press, Tokyo (1996, in Japanese).
  7. Iwata H, Ishizuka M. and Fujita S. Animal as a indicator of highly toxic organic pollutants: Availability of biomarker to detect environmental pollution. J. Vet. Med., 49: 665-669 (1996, in Japanese).
  8. Iwata H, Tanabe S. and Tatsukawa R. Accumulation of organotin compounds in higher trophic animals. In: Proceedings of Otsuchi Manne Research Center Report, Vol. 21, pp. 61-62, Iwate (1996, in Japanese).

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