Original Articles

1. Mizuki Maruyama, Nana Ushine, Yukiko Watanabe, Chihiro Ishii, Keisuke Saito, Hidefumi Sakai, Takeshi Kuritani, Rio Doya, Kohei Ogasawara, Yoshinori Ikenaka, Yared Beyene Yohannes, Mayumi Ishizuka, Shouta M.M. Nakayama (Corresponding). Current situation of lead (Pb) exposure in raptors and waterfowl in Japan and difference in sensitivity to in vitro lead exposure among avian species. Environmental Pollution. 123907 (2024) DOI: 10.1016/j.envpol.2024.123907
2. Nyein Chan Soe, Yared Beyene Yohannes, Takamitsu Ohigashi, Hokuto Nakata, Chikae Tatsumi, Yoshitaka Uchida, Walubita Mufalo, Mayumi Ito, Tsutomu Sato, Toshifumi Igarashi, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta M. M. Nakayama (Corresponding). Effect of chicken manure amendment on lead burden in mice: exposure to lead-spiked soil. Journal of Soils and Sediments. (2024) DOI: 10.1007/s11368-024-03769-y
3. So Shinya, Mariko Sashika, Miku Minamikawa, Tetsuji Itoh, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M. M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka. Pesticide Contamination Levels in the Stomach Contents of Wild Raccoons (Procyon lotor) and Masked Palm Civets (Paguma larvata) in Japan. Environmental Toxicology and Chemistry. (2024) DOI: 10.1002/etc.5828
4. Tetsushi Hirano, Shuji Ohno, Yoshinori Ikenaka, Kanoko Onaru, Shizuka Kubo, Yuka Miyata, Mizuki Maeda, Youhei Mantani, Toshifumi Yokoyama, Collins Nimako, Yared Beyene Yohannes, Shouta M.M. Nakayama, Mayumi Ishizuka, Nobuhiko Hoshi. Quantification of the tissue distribution and accumulation of the neonicotinoid pesticide clothianidin and its metabolites in maternal and fetal mice. Toxicology and Applied Pharmacology. 484:116847 (2024) DOI: 10.1016/j.taap.2024.116847
5. Manfo FPT, Nimako C, Nantia EA, Suh CF, Chenwi SP, Cho-Ngwa F, Moundipa PF, Nakayama SMM, Ishizuka M, Ikenaka Y. Exposure of Male Farmers and Nonfarmers to Neonicotinoid Pesticides in the South-West and Littoral Regions of Cameroon: A Comparative Study. Environmental Toxicology and Chemistry. (2024) DOI: 10.1002/etc.5842
6. Nyein Chan Soe, Yared Beyene Yohannes, Andrew Kataba, Madalitso Tembo, John Yabe, Golden Zyambo, Kenneth Chawinga, Kaampwe Muzandu, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta MM Nakayama (Corresponding). Metals and arsenic distribution in stray dogs’ tissues around a lead-zinc mine in Kabwe, Zambia. Environmental Science and Pollution Research. 31, 12083–12093 (2024) DOI: 10.1007/s11356-024-31948-4
7. Walubita Mufalo, Takahiko Arima, Toshifumi Igarashi, Mayumi Ito, Tsutomu Sato, Shingo Tomiyama, Imasiku Nyambe, Carlito Baltazar Tabelin, Hokuto Nakata, Shouta MM Nakayama, Mayumi Ishizuka. Insights on hazardous metal bioaccessibility, and groundwater impacted by Zn residues from a legacy mine and risk evaluation of adjacent soils. Environmental Geochemistry and Health. 46:64 (2024) DOI: 10.1007/s10653-024-01864-0
8. Takashi Fujimori *(Co-Corresponding), Haruya Toyomaki, Kenji Shiota, Hokuto Nakata, John Yabe, Kaampwe Muzandu, Kenneth Chawinga, Rio Doya, Nyein Chan Soe, Mayumi Ishizuka, Shouta MM Nakayama *(Co-Corresponding). Lead Speciation in Body Tissues, Gastrointestinal Contents and Feces of Lead-exposed Wild Rats (Rattus rattus). Science of the Total Environment. 908: 168297 (2024) DOI: 10.1016/j.scitotenv.2023.168297
9. Kraisiri Khidkhan, Fuyu Yasuhira, Aksorn Saengtienchai, Chaiyan Kasorndorkbua, Ratiwan Sitdhibutr, Kohei Ogasawara, Hikaru Adachi, Yukiko Watanabe, Keisuke Saito, Hidefumi Sakai, Kazuo Horikoshi, Hajime Suzuki, Yusuke K. Kawai, Kazuki Takeda, Yared B. Yohannes, Yoshinori Ikenaka, Barnett A Rattner, Mayumi Ishizuka, Shouta M.M. Nakayama (Corresponding). Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors. Environmental Pollution. 122837 (2024) DOI: 10.1016/j.envpol.2023.122837

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Original Articles

1. Kohei Ogasawara, Naoki Yamada, Shouta MM Nakayama, Yukiko Watanabe, Keisuke Saito, Akane Chiba, Yoshitake Uchida, Kaoru Ueda, Yasunori Takenaka, Kentaro Kazama, Mami Kazama, Junya Yamagishi, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka. Surveys of eleven species of wild and zoo birds and feeding experiments in white-tailed eagles reveal differences in the composition of the avian gut microbiome based on dietary habits between and within species. Journal of Veterinary Medical Sciences. 85(12): 1355-1365 (2023) DOI: 10.1292/jvms.23-0138
2. Collins NIMAKO, Shouta M. M. NAKAYAMA, Yared Beyene YOHANNES, Yoshinori IKENAKA, Mayumi ISHIZUKA. Status Report on Neonicotinoid Pollution in Japan: Emphasis on Human, Animal, and Environmental Health. Environmental Monitoring and Contaminants Research. 3:69-91 (2023) DOI: 10.5985/emcr.20230004
3. Nana Ushine, Makoto Ozawa, Shouta M. M. Nakayama, Mayumi Ishizuka, Takuya Kato, Shin-ichi Hayama Evaluation of the Effect of Pb Pollution on Avian Influenza Virus-Specific Antibody Production in Black-Headed Gulls (Chroicocephalus ridibundus). Animals. 13(14), 2338 (2023) DOI: 10.3390/ani13142338
4. Kanami Watanabe, Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Mayumi Ishizuka. A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A. Animals. 13(12), 1939 (2023) DOI: 10.3390/ani13121939
5. Andrew Kataba, Yared Beyene Yohannes, Hokuto Nakata, John Yabe, Haruya Toyomaki, Kaampwe Muzandu, Golden Zyambo, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka* (Co-Corresponding), Shouta MM Nakayama *(Co-Corresponding). Association between chronic environmental lead (Pb) exposure and cytokines in males and females of reproductive age from Kabwe, Zambia. Int. J. Environ. Res. Public Health. 20(8), 5596 (2023) DOI:10.3390/ijerph20085596
6. Yuko Kihara, Yohsuke Makino, Masaaki Yokoyama, Fumiko Chiba, Aki Tanaka, Shouta M.M. Nakayama, Shin-ichi Hayama, Mayumi Ishizuka, Kurt B. Nolte, Hirotaro Iwase. X-ray analytic microscopy with CT-guided sample extraction to analyze potential projectile fragments in a dead serow. Legal Medicine. 63, 102257 (2023) DOI:10.1016/j.legalmed.2023.102257
7. Walubita Mufalo, Pawit Tangviroon, Takahiko Arima, Toshifumi Igarashi, Mayumi Ito, Tsutomu Sato, Kenta Noto, Takeshi Kawashima, Imasiku Nyambe, Hokuto Nakata, Shouta M.M. Nakayama, Mayumi Ishizuka. Immobilization of Pb and Zn leached from mining residue materials in Kabwe, Zambia: Performance of calcined dolomite in column experiments. Journal of Geochemical Exploration. 249, 107209 (2023) DOI:10.1016/j.gexplo.2023.107209
8. So Shinya,Devinda S. Muthusinghe, Nobuo Koizumi, Kumiko Yoshimatsu, Shouta M. M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka. Effects of Diazinon Exposure on Urinary Shedding of Lepto-spira interrogans Serogroup Hebdomadis in Mice. Toxics. 11(4), 361 (2023) DOI:10.3390/toxics11040361
9. Kraisiri Khidkhan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M. M. Nakayama, Kei Nomiyama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka. Biological effects related to exposure to polychlorinated biphenyl (PCB) and decabromodiphenyl ether (BDE-209) on cats. PlosONE. 18(1): e0277689 (2023) DOI: 10.1371/journal.pone.0277689
10. Kodai MOTOHIRA, Yared Beyene YOHANNES, Yoshinori IKENAKA, Akifumi EGUCHI, Shouta MM NAKAYAMA, Victor WEPENER, Nico J SMIT, Johan HJ VAN VUREN, Mayumi ISHIZUKA. Investigation of dichlorodiphenyltrichloroethane (DDT) on xenobiotic enzyme disruption and metabolomic bile acid biosynthesis in DDT-sprayed areas using wild rats. Journal of Veterinary Medical Science. 85 (2), 236-243 (2023) DOI: 10.1292/jvms.22-0490
11. Mitsuki Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai, Hazuki Mizukawa, Yoko Mitani, Kei Nomyama, Shinsuke Tanabe, Mayumi Ishizuka. Sulfotransferases (SULTs), enzymatic and genetic variation in Carnivora: Limited sulfation capacity in pinnipeds. Comparative Biochemistry and Physiology, Part C. 263: 109476 (2023) DOI: 10.1016/j.cbpc.2022.109476

▲このページの先頭へ

Original Articles

1. Daichi Yamada, Masato Hiwatari, Daiju Narita, Peter Hangoma, Bona Chitah, Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Mayumi Ito, Toshifumi Igarashi, Mayumi Ishizuka, Golden Zyambo. Social cost of mining-related lead (Pb) pollution in Kabwe, Zambia, and potential remediation measures. Science of the Total Environment. 161281 (2022) DOI: 10.1016/j.scitotenv.2022.161281
2. Bataa B, Motohira K, Dugar D, Sainnokhoi TA, Gendenpil L, Sainnokhoi T, Pelden B, Yohannes YB, Ganzorig S, Nakayama SMM, Ishizuka M, Ikenaka Y. Accumulation of Metals in the Environment and Grazing Livestock near A Mongolian Mining Area. Toxics. 10(12): 773 (2022) DOI: 10.3390/toxics10120773
3. So Shinya, Yusuke Kawai, Mitsuki Kondo, Shouta MM Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka Characteristics of cytochrome P450-dependent metabolism against acetamiprid in the musk shrew (Suncus murinus). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 109537 (2022) DOI: 10.1016/j.cbpc.2022.109537
4. Anri Hirai, Ryo Yamazaki, Atsushi Kobayashi, Takashi Kimura, Kei Nomiyama, Shuichi Shimma, Shouta M.M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka. Detection of Changes in Monoamine Neurotransmitters by the Neonicotinoid Pesticide Imidacloprid Using Mass Spectrometry. Toxics. 10(11), 696 (2022) DOI: 10.3390/toxics10110696
5. Thandar Oo, Noboru Sasaki, Yoshinori Ikenaka, Ichise Takahiro, Noriyuki Nagata, Nozomu Yokoyama, Kazuyoshi Sasaoka, Keitaro Morishita, Kensuke Nakamura, Mitsuyoshi Takiguchi. Serum Steroid Profiling of Hepatocellular Carcinoma associated with Hyperadrenocorticism in Dogs: A Preliminary Study. Frontiers Veterinary Science. 1014792 (2022) DOI: 10.3389/fvets.2022.1014792
6. Shizuka Kubo, Tetsushi Hirano, Yuka Miyata, Shuji Ohno, Kanoko Onaru, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka, Youhei Mantani, Toshifumi Yokoyama, Nobuhiko Hoshi. Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice. Toxicology and Applied Pharmacology. 456:116283 (2022) DOI: 10.1016/j.taap.2022.116283
7. So Shinya, Yared Beyene Yohannes, Yoshinori Ikenaka, Shouta MM Nakayama, Mayumi Ishizuka, Shoichi Fujita. Characteristics of cytochrome P450-dependent metabolism in the liver of the wild raccoon, Procyon lotor. JVMS. 84(12): 1665-1672 (2022) DOI: 10.1292/jvms.22-0182
8. Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Yusuke K. Kawai, Mayumi Ishizuka. Duplication, loss, and evolutionary features of specific UDP-glucuronosyltransferase genes in Carnivora (Mammalia, Laurasiatheria). Animals. 12(21): 2954 (2022) DOI: 10.3390/ani12212954
9. Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Yusuke K. Kawai, Mayumi Ishizuka. Specific gene duplication and loss of Cytochrome P450 in families 1-3 in Carnivora (Mammalia, Laurasiatheria). Animals. 12(20): 2821 (2022) DOI: 10.3390/ani12202821
10. Nana Ushine, Osamu Kurata, Yoshikazu Tanaka, Shouta MM Nakayama, Mayumi Ishizuka, Takuya Kato, Shin-ichi Hayama. Estimation of the reference lead (Pb) concentration levels affecting immune cells in the blood of Black-headed Gulls (Chroicocephalus ridibundus, Laridae) Avian Conservation and Ecology. 17 (2):40 (2022)DOI: 10.5751/ACE-02336-170240
11. Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Haruya Toyomaki, Andrew Kataba, Hokuto Nakata, Kaampwe Muzandu, Chihiro Miyashita, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka. Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb). Epigenetics. 17(13):2377-2388 (2022) DOI: 10.1080/15592294.2022.2123924
12. Hokuto NAKATA, Shouta M. M. NAKAYAMA, John YABE, Kaampwe MUZANDU, Andrew KATABA, Yoshinori IKENAKA, Mayumi ISHIZUKA. Interdisciplinary approach to addressing lead pollution caused by mining activity in Kabwe, The Republic of Zambia. Environmental Monitoring and Contaminants Research. 2: 94-111 (2022) DOI: 10.5985/emcr.20220004
13. Hokuto Nakata, Shouta M.M. Nakayama, Andrew Kataba, Haruya Toyomaki, Rio Doya, Yared Beyene Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka. Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague–Dawley rats? Journal of Functional Foods. 97: 105242 (2022) DOI: 10.1016/j.jff.2022.105242
14. Kazuki Takeda, Kosuke Manago, Ayuko Morita, Yusuke K. Kawai, Nobuaki Yasuo, Masakazu Sekijima, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuo Horikoshi, Hajime Suzuki, Mayumi Ishizuka, Shouta M.M.Nakayama (Corresponding). Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon). Ecotoxicology and Environmental Safety 243 (15): 113971 (2022) DOI: 10.1016/j.ecoenv.2022.113971
15. Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Kaampwe Muzandu, Andrew Kataba, Atsuko Ikeda-Araki, Marie-Noel Brune Drisse, Lesley Jayne Onyon, Julia Gorman, Poudel Kritika, Hisanori Fukunaga, Yoshinori Ikenaka, Reiko Kishi, Mayumi Ishizuka. Narrative review of lead poisoning in humans caused by industrial activities and measures compatible with sustainable industrial activities in Republic of Zambia. Science of the Total Environment. 850: 157833 (2022) DOI: 10.1016/j.scitotenv.2022.157833
16. Chihiro Ishii, Yusuke K. Kawai, Yoshinori Ikenaka, Naoya Maekawa, Osamu Ichii, Shouta M.M. Nakayama, Mayumi Ishizuka. Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens. Poultry Science. 102011 (2022) DOI: 10.1016/j.psj.2022.102011
17. Hiroshi Sato (#Equal contribution), Chihiro Ishii (#Equal contribution), Shouta M.M. Nakayama, Takahiro Ichise, Keisuke Saito, Yukiko Watanabe, Kohei Ogasawara, Ryota Torimoto, Atsushi Kobayashi, Takashi Kimura, Yukiko Nakamura, Junya Yamagishi, Yoshinori Ikenaka, Mayumi Ishizuka . Behavior and toxic effects of Pb in a waterfowl model with oral exposure to Pb shots: Investigating Pb exposure in wild birds. Environmental Pollution. 119580 (2022) DOI: 10.1016/j.envpol.2022.119580
18. Kei Nomiyama, Yasuo Yamamoto, Akifumi Eguchi, Hiroyuki Nishikawa, Hazuki Mizukawa, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka. Health impact assessment of pet cats caused by organohalogen contaminants by serum metabolomics and thyroid hormone analysis. Science of the Total Environment. 156490 (2022) DOI: 10.1016/j.scitotenv.2022.156490
19. Yasuhiro Uno, Makiko Shimizu, Yurie Ogawa, Miaki Makiguchi, Hiroaki Kawaguchi, Osamu Yamato, Mayumi Ishizuka, Hiroshi Yamazaki. Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats. Biochemical Pharmacology. 202:115125 (2022) DOI: 10.1016/j.bcp.2022.115125
20. Yasuhiro Uno, Norie Murayama, Moe Ijiri, Hiroaki Kawaguchi, Osamu Yamato, Mitsuya Shiraishi, Atsushi Asano, Hiroki Teraoka, Hazuki Mizukawa, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Hiroshi Yamazaki. Cytochrome P450 2J (CYP2J) Genes in Dogs, Cats, and Pigs Are Expressed and Encode Functional Drug-Metabolizing Enzymes. Drug Metabolism and Disposition. DMD-AR-2022-000930 (2022) DOI: 10.1124/dmd.122.000930
21. Hampton Jordan O, Pay James M, Katzner Todd E, Arnemo Jon M, Pokras Mark A, Buenz Eric, Kanstrup Niels, Thomas Vernon G, Uhart Marcela, Lambertucci Sergio A, Krone Oliver, Singh Navinder J, Naidoo Vinny, Ishizuka Mayumi, Saito Keisuke, Helander Björn, Green Rhys E. Managing macropods without poisoning ecosystems. Ecological Management & Restoration. (2022) DOI: 10.1111/emr.12555
22. Shinsaku Nakamura, Toshifumi Igarashi, Yoshitaka Uchida, Mayumi Ito, Kazuyo Hirose, Tsutomu Sato, Walubita Mufalo, Meki Chirwa, Imasiku Nyambe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka. Impacts of Surface Water on Windborne Lead Dispersion from the Zinc Plant Leach Residue in Kabwe, Zambia. Minerals. 12(5):535 (2022) DOI: 10.3390/min12050535
23. So Shinya, Mariko Sashika, Miku Minamikawa, Tetsuji Itoh, Yared Beyene Yohannes, Shouta MM Nakayama, Mayumi Ishizuka, Collins Nimako, Yoshinori Ikenaka. Estimation of the Effects of Neonicotinoid Insecticides on Wild Raccoon, Procyon lotor, in Hokkaido, Japan: Urinary Concentrations and Ability for Hepatic Metabolism of Neonicotinoids. Environmental Toxicology and Chemistry (2022, in press) DOI: 10.1002/etc.5349
24. Golden Zyambo, John Yabe, Kaampwe Muzandu, Ethel M’kandawire, Kennedy Choongo, Andrew Kataba, Kenneth Chawinga, Allan Liazambi, Shouta M. M. Nakayama, Hokuto Nakata, Mayumi Ishizuka. Human Health Risk Assessment from Lead Exposure through Consumption of Raw Cow Milk from Free-Range Cattle Reared in the Vicinity of a Lead–Zinc Mine in Kabwe. Int. J. Environ. Res. Public Health. 19(8): 4757 (2022) DOI: 10.3390/ijerph19084757
25. Marthias Silwamba, Mayumi Ito, Naoki Hiroyoshi, Carlito Baltazar Tabelin, Ryota Hashizume, Tomoki Fukushima, Ilhwan Park, Sanghee Jeon, Toshifumi Igarashi, Tsutomu Sato, Imasiku Nyambe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka. Alkaline leaching and concurrent cementation of dissolved Pb and Zn from zinc plant leach residues. Minerals. 12(4): 393 (2022) DOI: 10.3390/min12040393
26. Misaki NISHI, Shouta SUGIO, Tetsushi HIRANO, Daisuke KATO, Hiroaki WAKE, Asuka SHODA, Midori MURATA, Yoshinori IKENAKA, Yoshiaki TABUCHI, Youhei MANTANI, Toshifumi YOKOYAMA and Nobuhiko HOSHI. Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy in vivo imaging. JVMS (2022, in press)
27. Furuta Y., Miura F., Ichise T., Nakayama M.M. S., Ikenaka Y., Zorigt T., Tsujinouchi M., Ishizuka M., Ito T., Higashi H. A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand. PLOS ONE. 17(3) : e0265225 (2022) DOI: 10.1371/journal.pone.0265225
28. Noboru Sasaki, Yoshinori Ikenaka, Keisuke Aoshima, Teiichiro Aoyagi, Nobuki Kudo, Kensuke Nakamura and Mitsuyoshi TAKIGUCHI. Safety Assessment of Ultrasound-assisted Intravesical Chemotherapy in Normal Dogs: A Pilot Study. Frontiers in Pharmacology (2022, in press)
29. Anri Hirai, Shouta Sugio, Collins Nimako, Shouta M.M. Nakayama, Keisuke Kato, Keisuke Takahashi, Koji Arizono, Tetsushi Hirano, Nobuhiko Hoshi, Kazutoshi Fujioka, Kumiko Taira, Mayumi Ishizuka, Hiroaki Wake, Yoshinori Ikenaka. Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides. Scientific reports. 12: 5114 (2022) DOI: 10.1038/s41598-022-09038-7
30. Kazuhiro Toyoda, Shota Nakano, Shunitz Tanaka, Kawawa Banda, Imasiku A. Nyambe, Tsuyoshi Ishikawa, Shouta Nakayama, Mayumi Ishizuka. Geochemical identification of particulate lead pollution in shallow groundwater in inhabited areas in Kabwe, Zambia. Applied Geochemistry. 139 :105215 (2022) DOI: 10.1016/j.apgeochem.2022.105215
31. Nimako, C., Ichise, T., Hasegawa, H., Akoto, I., Boadi, N., Taira, K., Fujioka, K., Isoda, N., Nakayama, S.M.M., Ishizuka, M. and Ikenaka, Y. Assessment of amerliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population. Environment International. 162: 107169 (2022) DOI: 10.1016/j.envint.2022.107169
32. Hokuto Nakata († Equal contribution), Akifumi Eguchi († Equal contribution), Shouta M. M. Nakayama (* Co-Corresponding), John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, Chisato Mori, Mayumi Ishizuka (* Co-Corresponding). Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study. Int. J. Environ. Res. Public Health. 19(1): 541 (2022) DOI: 10.3390/ijerph19010541
33. Given Moonga, Moses N. Chisola, Ursula Berger, Dennis Nowak, John Yabe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka, Stephan Bose-O’Reilly. Geospatial approach to investigate spatial clustering and hotspots of blood lead levels in children within Kabwe, Zambia. Environmental Research. 207:112646 (2022) DOI: 10.1016/j.envres.2021.112646

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Original Articles

1. Andrew Kataba, Tarryn L. Botha, Shouta M.M Nakayama, Yared B. Yohannes, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka. Environmentally relevant lead (Pb) water concentration induce toxicity in zebrafish (Danio rerio) larvae. Comparative Biochemistry and Physiology, Part C (2021, in press)
2. Collins Nimako, Anri Hirai, Takahiro Ichise, Osei Akoto, Shouta M.M. Nakayama, Kumiko Taira, Kazutoshi Fujioka, Mayumi Ishizuka, Yoshinori Ikenaka. Neonicotinoid residues in commercial Japanese tea leaves produced by organic and conventional farming methods. Toxicology Reports. 8:1657-1664 (2021) DOI: 10.1016/j.toxrep.2021.09.002
3. Walubita Mufalo, Pawit Tangviroon, Toshifumi Igarashi, Mayumi Ito, Tsutomu Sato, Meki Chirwa, Imasiku Nyambe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka. Solid-phase partitioning and leaching behavior of Pb and Zn from playground soils in Kabwe, Zambia. Toxics. 9(10) :248 (2021) DOI: 10.3390/toxics9100248
4. Tetsushi Hirano, Nihei Suzuki, Yoshinori Ikenaka, Nobuhiko Hoshi, Yoshiaki Tabuchi. Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition. Toxicology and Applied Pharmacology. 430:115723 (2021) DOI: 10.1016/j.taap.2021.115723
5. Noboru Sasaki, Thandar Oo, Yoshikazu Yasuda, Takahiro Ichise, Noriyuki Nagata, Nozomu Yokoyama, Kazuyoshi Sasaoka, Keitaro Morishita, Shouta MM Nakayama, Mayumi Ishizuka,　Kensuke Nakamura, Mitsuyoshi Takiguchi, Yoshinori Ikenaka. Simultaneous steroids measurement in dogs with hyperadrenocorticism using a column-switching liquid chromatography-tandem mass spectrometry method. JVMS (2021) DOI: 10.1292/jvms.21-0406
6. Andrew KATABA, Shouta M.M. NAKAYAMA (Co-corresponding), Yared Beyene YOHANNES, Haruya TOYOMAKI, Hokuto NAKATA, Yoshinori IKENAKA, Mayumi ISHIZUKA (Co-corresponding). Effects of zinc on tissue uptake and toxicity of lead in Sprague Dawley rat. JVMS (2021) DOI: 10.1292/jvms.20-0684
7. Yared Beyene Yohannes (Equal contribution), Shouta M. M. Nakayama (Equal contribution, Co-corresponding), John Yabe, Haruya Toyomaki, Andrew Kataba, Hokuto Nakata, Kaampwe Muzandu, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka (Co-corresponding). Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia. Environ Sci Pollut Res. (2021) DOI: 10.1007/s11356-021-16098-1
8. Shinsaku Nakamura, Toshifumi Igarashi, Yoshitaka Uchida, Mayumi Ito, Kazuyo Hirose, Tsutomu Sato, Walubita Mufalo, Meki Chirwa, Imasiku Nyambe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka. Evaluation of Dispersion of Lead-Bearing Mine Wastes in Kabwe District, Zambia. Minerals. 11(8) :901 (2021) DOI: 10.3390/min11080901
9. Collins NIMAKO, Yoshinori IKENAKA, Osei Akoto, Kazutoshi FUJIOKA, Kumiko TAIRA, Koji ARIZONO, Keisuke KATO, Keisuke TAKAHASHI, Shouta M.M. NAKAYAMA, Takahiro ICHISE, Mayumi ISHIZUKA. Simultaneous Quantification of Imidacloprid and its Metabolites in Tissues of Mice upon Chronic Low-dose Administration of Imidacloprid. Journal of Chromatography A. 1652: 462350 (2021) DOI: 10.1016/j.chroma.2021.462350
10. Tzu-Hsuen Yuan, Meng-Ting Yu, Yoshinori Ikenaka, Yi-Hsuan Chen, Shoji F Nakayama, Chang-Chuan Chan. Characteristics of neonicotinoid and metabolite residues in Taiwanese tea leaves. Journal of The Science of Food and Agriculture (2021, in press) DOI: 10.1002/jsfa.11363
11. Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama* (Corresponding), Yared Beyene Yohannes, Kaampwe Muzandu, Tiza Mufune, Hokuto Nakata, Yoshinori Ikenaka, Takeshi Kuritani, Mitsuhiro Nakagawa, Kennedy Choongo, Mayumi Ishizuka. Lead concentrations and isotope ratios in blood, breastmilk and feces: contribution of both lactation and soil/dust exposure to infants in a lead mining area, Kabwe, Zambia. Environmental Pollution. 117456. (2021) DOI: 10.1016/j.envpol.2021.117456
12. Jumpei Yamazaki, Haruya Toyomaki, Shouta M.M. Nakayama*（Corresponding), John Yabe, Kaampwe Muzandu, Jaroslav Jelinek, Shoko Yokoyama, Yoshinori Ikenaka, Mitsuyoshi Takiguchi, Mayumi Ishizuka. Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia. Environmental Pollution. 117229 (2021) DOI: 10.1016/j.envpol.2021.117229
13. Ryu Miura, Atsuko Araki, Toru Ishihara, Kunio Miyake, Chihiro Miyashita, Tamie Nakajima, Kobayashi Sumitaka, Mayumi Ishizuka, Takeo Kubota, Reiko Kishi. Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children’s Health. Science of the Total Environment. 147035 (2021) DOI: 10.1016/j.scitotenv.2021.147035
14. Y. Sajiki; S. Konnai; Y. Ikenaka; T. Okagawa; N. Maekawa; C. Logullo; I. da Silva Vaz; S. Murata; K. Ohashi. Prostaglandin-related immune suppression in cattle. Veterinary Immunology and Immunopathology. 110238 (2021) DOI: 10.1016/j.vetimm.2021.110238
15. Collins Nimako, Yoshinori Ikenaka, Osei Akoto, Nesta Bortey-Sam, Takahiro Ichise, Shouta M.M. Nakayama, Kwadwo A. Asante, Kazutoshi Fujioka, Kumiko Taira, Mayumi Ishizuka. Human Exposures to Neonicotinoids in Kumasi, Ghana. Environmental Toxicology and Chemistry (in press, 2021) DOI: 10.1002/etc.5065
16. Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Jussiaea V. BARIUAN, Atsushi KOBAYASHI, Ryo YAMAZAKI, Kumiko TAIRA, Nobuhiko HOSHI, Tetsushi HIRANO, Shouta M. M. NAKAYAMA, Mayumi ISHIZUKA. Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice. JVMS (2021) DOI: 10.1292/jvms.20-0479
17. Hokuto Nakata, Harukazu Tohyama, Wakako Fujita, Shouta M.M. Nakayama, Mayumi Ishizuka, John Yabe, Nosiku S. Munyinda, Doreen Sakala, Kennedy Choongo, Shojiro Yamasaki, Natsumi Nagai, Takahiko Yoshida, Takeshi Saito. The impact of elevated blood lead levels in children on maternal health-related quality of life. Chemosphere. 130490 (2021) DOI: 10.1016/j.chemosphere.2021.130490
18. Ryouta Torimoto, Chihiro Ishii, Hiroshi Sato, Keisuke Saito, Yukiko Watanabe, Kohei Ogasawara, Ayano Kubota, Takehisa Matsukawa, Kazuhito Yokoyama, Atsushi Kobayashi*, Takashi Kimura, Shouta M. M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka. Analysis of lead distribution in avian organs by LA-ICP-MS: study of experimentally lead-exposed ducks and kites. Environmental Pollution. 117086 (2021) DOI: 10.1016/j.envpol.2021.117086
19. Tomohiro Suzuki, Anri Hirai, Kraisiri Khidkhana, Collins Nimako, Takahiro Ichise, Kazuki Takeda, Hazuki Mizukawa, Shouta M.M. Nakayama, Kei Nomiyama, Nobuhiko Hoshi, Mizuki Maeda, Tetsushi Hirano, Kazuyoshi Sasaoka, Noboru Sasaki, Mitsuyoshi Takiguchi, Mayumi Ishizuka, Yoshinori Ikenaka. The effects of fipronil on emotional and cognitive behaviors in mammals. Pesticide Biochemistry and Physiology. 104847 (2021) DOI: 10.1016/j.pestbp.2021.104847
20. Akiko Shoji, Kyle H. Elliott, Yutaka Watanuki, Niladri Basu, Shannon Whelan, Joshua Cunningham, Scott Hatch, Hazuki Mizukawa, Shouta M.M.Nakayama, YoshinoriIkenaka, Mayumi Ishizuka, StéphaneAris-Brosou. Geolocators link marine mercury with levels in wild seabirds throughout their annual cycle: consequences for trans-ecosystem biotransport. Environmental Pollution. 117035 (2021) DOI: 10.1016/j.envpol.2021.117035
21. Yoshiya Yamamura, Kazuki Takeda, Yusuke K. Kawai, Yoshinori Ikenaka, Chiyo Kitayama, Satomi Kondo, Chiho Kezuka, Mari Taniguchi, Mayumi Ishizuka, Shouta M.M. Nakayama (Corresponding). Sensitivity of turtles to anticoagulant rodenticides: risk assessment for green sea turtles (Chelonia mydas) in the Ogasawara Islands and comparison of warfarin sensitivity among turtle species. Aquatic Toxicology. 233: 105792 (2021) DOI: 10.1016/j.aquatox.2021.105792
22. Noboru Sasaki, Yoshinori Ikenaka, Yumiko Inoue, Takahiro Ichise, Noriyuki Nagata, Mayumi Ishizuka, Shouta MM Nakayama, Kensuke Nakamura, Mitsuyoshi Takiguchi. Urinary free metanephrines measurement in dogs with adrenal gland diseases using a new simple liquid chromatography tandem mass spectrometry method. JVMS. (2021, in press)
23. Tetsushi Hirano, Yuka Miyata, Shizuka Kubo, Shuji Ohno, Kanoko Onaru, Mizuki Maeda, Sayaka Kitauchi, Misaki Nishi, Yoshiaki Tabuchi, Yoshinori Ikenaka, Takahiro Ichise, Shouta M M Nakayama, Mayumi Ishizuka, Koji Arizono, Keisuke Takahashi, Keisuke Kato, Youhei Mantani, Toshifumi Yokoyama, Nobuhiko Hoshi. Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice. Toxicology Letters. 342: 95-103 (2021) DOI: 10.1016/j.toxlet.2021.02.010
24. Mayuka Uchida, Ippei Suzuki, Keizo Ito, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M. M. Nakayama, Tsutomu Tamura, Kenji Konishi, Takeharu Bando, Yoko Mitani. Estimation of the feeding record of pregnant Antarctic minke whales (Balaenoptera bonaerensis) using carbon and nitrogen stable isotope analysis of baleen plates. Polar Biology. (2021) DOI: 10.1007/s00300-021-02816-5
25. Nakata H (Equal contribution), Nakayama SMM (Equal contribution, Co-corresponding), Yabe J, Muzandu K, Toyomaki H, Yohannes YB, Kataba A, Zyambo G, Ikenaka Y, Choongo K, Ishizuka M (Co-corresponding). Assessment of LeadCare® II analysis for testing of a wide range of blood lead levels in comparison with ICP–MS analysis. Chemosphere. 129832 (2021) DOI: 10.1016/j.chemosphere.2021.129832
26. Andrew Kataba, Shouta MM Nakayama (Co-corresponding), Hokuto Nakata, Haruya Toyomaki, Yared B Yohannes, John Yabe, Kaampwe Muzandu, Golden Zyambo, Ayano Kubota, Takehisa Matsukawa, Kazuhito Yokoyama, Yoshinori Ikenaka, Mayumi Ishizuka (Co-corresponding). An investigation of the wild rat crown incisor as an indicator of lead (Pb) exposure using inductively couple plasma mass spectrometry (ICP-MS) and laser ablation-ICP-MS. International Journal of Environmental Research and Public health. 18(2):767 (2021) DOI: 10.3390/ijerph18020767
27. Kazuki Takeda, Yoshinori Ikenaka, Denis Fourches, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Dhoha Triki, Xinhao Li, Manabu Igarashi, Tsutomu Tanikawa, Mayumi Ishizuka. The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus). Pesticide Biochemistry and Physiology. 104774 (2021) DOI: 10.1016/j.pestbp.2021.104774
28. Hokuto Nakata, Shouta M.M. Nakayama, Andrew Kataba, Yared Beyene Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka. Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on parameters relating to lead poisoning and obesity in C57BL/6J mice. Journal of Functional Foods. (2021, in press)
29. Yared B. Yohannes, Shouta M.M. Nakayama (Co-corresponding), John Yabe, Haruya Toyomaki, Andrew Kataba, Hokuto Nakata, Kaampwe Muzandu, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka (Co-corresponding). Delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes polymorphisms in children residing in an abandoned lead-zinc mine area. Meta Gene. 27 (2021) DOI: 10.1016/j.mgene.2020.100838
30. Ruan Gerber, Hindrik Bouwman, Danny Govender, Mayumi Ishizuka, Yoshinori Ikenaka, Yared B.Yohannes, Nico J.Smit, Victor Wepener. Levels of DDTs and other organochlorine pesticides in healthy wild Nile crocodiles (Crocodylus niloticus) from a flagship conservation area. Chemosphere. 128368 (2021)DOI: 10.1016/j.chemosphere.2020.128368
31. Hiroshi Ishikawa, Mayuko Otsuki, Tsutomu Tamura, Kenji Konishi, Takaharu Bando, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M.Nakayama, Yoko Mitani. Foraging ecology of mature male Antarctic minke whales (Balaenoptera bonaerensis) revealed by stable isotope analysis of baleen plates. Polar Science. 100785 (2021) DOI: 10.1016/j.polar.2021.100785

▲このページの先頭へ

Original Articles

1. Patricia N. Mwilola, Ikabongo Mukumbuta, Victor Shitumbanuma, Benson H. Chishala, Yoshitaka Uchida, Hokuto Nakata, Shouta MM Nakayama, Mayumi Ishizuka. Lead, Zinc and Cadmium Accumulation, and Associated Health Risks, in Maize Grown Near the Kabwe Mine in Zambia in Response to Organic and Inorganic Soil Amendments. Int. J. Environ. Res. Public Health. 17(23): 9038 (2020)DOI: 10.3390/ijerph17239038
2. Wilson Mwandira, Kazunori Nakashima, Satoru Kawasaki, Allison Arabelo, Kawawa Banda, Imasiku Nyambe, Meki Chirwa, Mayumi Ito, Tsutomu Sato, Toshifumi Igarashi, Hokuto Nakata, Shouta MM Nakayama, Mayumi Ishizuka. Biosorption of Pb (II) and Zn (II) from aqueous solution by Oceanobacillus profundus isolated from an abandoned mine. Scientific Reports. 10: 21189 (2020) DOI: 10.1038/s41598-020-78187-4
3. Kris A.G. Wyckhuys, Alexandre Aebi, Maarten F.I.J. Bijleveld van Lexmond, Carlos R. Bojaca, Jean-Marc Bonmatin, Lorenzo Furlan, Jairo A. Guerrero, Trinh V. Mai, Hoi V. Pham, Francisco Sanchez-Bayo, Yoshinori Ikenaka. Resolving the twin human and environmental health hazards of a plant-based diet. Environment International. 144: 106081 (2020) DOI: 10.1016/j.envint.2020.106081
4. Pawit Tangviroon, Kenta Noto, Toshifumi Igarashi, Takeshi Kawashima, Mayumi Ito, Tsutomu Sato, Walubita Mufalo, Meki Chirwa, Imasiku Nyambe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka. Immobilization of lead and zinc leached from mining residual materials in Kabwe, Zambia: Possibility of chemical immobilization by dolomite, calcinated dolomite, and magnesium oxide. Minerals. 10(9): 763 (2020) DOI: 10.3390/min10090763
5. Daichi Yamada, Masato Hiwatari, Peter Hangoma, Daiju Narita, Chrispin Mphuka, Bona Chitah, John Yabe, Shouta M.M. Nakayama, Hokuto Nakata, Kennedy Choongo, Mayumi Ishizuka. Assessing the population-wide exposure to lead pollution in Kabwe, Zambia: an econometric estimation based on survey data. Scientific Reports. 10: 15092 (2020) DOI: 10.1038/s41598-020-71998-5
6. Andrew Kataba, Tarryn L. Botha, Shouta M.M Nakayama, Yared B. Yohannes, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka. Acute exposure to environmentally relevant Pb levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio). Aquatic Toxicology. 105607 (2020) DOI: 10.1016/j.aquatox.2020.105607
7. Nakata H*, Nakayama SMM* (* Equal contribution), Yabe J, Muzandu K, Toyomaki H, Yohannes YB, Kataba A, Zyambo G, Ikenaka Y, Choongo K, Ishizuka M. Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia. Chemosphere.127788 (2020) DOI: 10.1016/j.chemosphere.2020.127788
8. Yoshii Y, von Rein I, Munthali K, Mwansa M, Nakata H, Nakayama S, Ishizuka M, Uchida Y. Evaluation of phytoremediation effects of chicken manure, urea and lemongrass (Cymbopogon citratus) to remediate a lead contaminated soil in Kabwe, Zambia. South African Journal of Plant and Soil. (2020, in press)
9. Silwamba M, Ito M, Hiroyoshi N, Tabelin CB, Fukushima T, Park I, Jeon S, Igarashi T, Sato T, Nyambe I, Chirwa M, Banda K, Nakata H, Nakayama SMM, Ishizuka M. Detoxification of lead-bearing zinc plant leach residues from Kabwe, Zambia by coupled extraction-cementation method. Journal of Environmental Chemical Engineering. 104197 (2020, in press) DOI: 10.1016/j.jece.2020.104197
10. Erasmus A, Ikenaka Y, Nakayama SMM, Ishizuka M, Smit NJ, Wepener V. Trophic transfer of pollutants within two intertidal rocky shore ecosystems in different biogeographic regions of South Africa. Marine Pollution Bulletin. 111309 (2020) DOI: 10.1016/j.marpolbul.2020.111309
11. Ushine N, Nakayama SMM, Ishizuka M, Sato T, Kurahashi Y, Wakayama E, Sugiura N, Hayama S. Relationship between blood test values and blood lead (Pb) levels in Black-headed gull (Chroicocephalus ridibundus: Laridae). JVMS. 2020 (in press)
12. Doya R*, Nakayama SMM* (* Equal Contribution), Nakata H, Toyomaki H, Yabe J, Muzandu K, Yohannes Y, Kataba A, Zyambo G, Ogawa T, Uchida Y, Ikenaka Y, Ishizuka M. Land Use in Habitat Affects Metal Concentrations in Wild Lizards Around a Former Lead Mining Site. Environmental Science & Technology. 2020 (in press) DOI: 10.1021/acs.est.0c00150
13. Ishii C, Ikenaka Y, Nakayama SMM, Kuritani T, Nakagawa M, Saito K, Watanabe Y, Ogasawara K, Onuma M, Haga A, Ishizuka M. Current situation regarding lead exposure in birds in Japan (2015 – 2018); lead exposure is still occurring. JVMS. 2020 (in press)
14. Yohannes YB, Nakayama SMM, Yabe J, Nakata H, Toyomaki H, Kataba A, Muzandu K, Ikenaka Y, Choongo K, Ishizuka M. Blood Lead Levels and Aberrant DNA Methylation of the ALAD and p16 Gene Promoters in Children Exposed to Environmental-Lead. Environmental Research . 109759 (2020) DOI: 10.1016/j.envres.2020.109759
15. Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Takiguchi M, Tanabe S, Ishizuka M. Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209). JVMS. 2020 (in press) DOI: 10.1292/jvms.20-0140
16. Silwanba M, Ito M, Hiroyoshi N, Tabelin CB, Hashizume R, Fukushima T, Park I, Jeon S, Igarashi T, Sato T, Chirwa M, Banda K, Nyambe I, Nakata H, Nakayama S, Ishizuka M. Recovery of Lead and Zinc from Zinc Plant Leach Residues by Concurrent Dissolution-Cementation Using Zero-Valent Aluminum in Chloride Medium. Metals. 10(4): 531 (2020) DOI: 10.3390/met10040531
17. Kazuki Takeda, Ayuko Morita, Yoshinori Ikenaka, Shouta M.M.Nakayama, Mayumi Ishizuka. Comparison of two reducing agents dithiothreitol and tris(3-hydroxypropyl)phosphine for in vitro kinetic assay of vitamin K epoxide reductase. Veterinary and Animal Science. 9: 100095 (2020) DOI: 10.1016/j.vas.2020.100095
18. Toyomaki H, Yabe J, Nakayama SMM, Yohannes YB, Muzandu K, Liazambi A, Ikenaka Y, Kuritani T, Nakagawa M, Ishizuka M. Factors associated with lead (Pb) exposure on dogs around a Pb mining area, Kabwe, Zambia. Chemosphere. 247: 125884 (2020) DOI: 10.1016/j.chemosphere.2020.125884.
19. Takada T, Yoneda N, Hirano T, Onaru K, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Nimako C, Ishizuka M, Ikenaka Y, Hoshi N. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. JVMS (2020, in press) DOI: 10.1292/jvms.19-0635
20. Ohno S, Ikenaka Y, Onaru K, Kubo S, Sakata N, Hirano T, Mantani Y, Yokoyama T, Takahashi K, Kato K, Arizono K, Ichise T, Nakayama SMM, Ishizuka M, Hoshi N. Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice. Toxicology Letters. 322:32-38 (2020) DOI: 10.1016/j.toxlet.2020.01.003
21. Kosuke Tanaka, Yutaka Watanuki, Hideshige Takada, Mayumi Ishizuka, Rei Yamashita, Mami Kazama, Nagako Hiki, Fumika Kashiwada, Kaoruko Mizukawa, Hazuki Mizukawa, David Hyrenbach, Michelle Hester, Yoshinori Ikenaka, Shouta M.M. Nakayama. In Vivo Accumulation of Plastic-Derived Chemicals into Seabird Tissues. Current biology. 30: 1-6 (2020) DOI: 10.1016/j.cub.2019.12.037
22. KosukeTanaka, Hideshige Takada, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka. Occurrence and concentrations of chemical additives in plastic fragments on a beach on the island of Kauai, Hawaii. Marine Pollution Bulletin. 150: 110732 (2020) DOI: 10.1016/j.marpolbul.2019.110732
23. Yabe J*, Nakayama SMM* (* Equal Contribution), Nakata H, Toyomaki H, Yohannes YB, Muzandu K, Kataba A, Zyambo G, Hiwatari M, Narita D, Yamada D, Hangoma P, Munyinda NS, Mufune T, Ikenaka Y, Choongo K, Ishizuka M. Current Trends of Blood Lead Levels, Distribution Patterns and Exposure Variations among Household Members in Kabwe, Zambia. Chemosphere. 125412 (2020, in press) DOI: 10.1016/j.chemosphere.2019.125412
24. Nakayama SMM, Morita A, Ikenaka Y, Kawai YK, Watanabe KP, Ishii C, Mizukawa H, Yohannes YB, Saito K, Watanabe Y, Ito M, Ohsawa N, Ishizuka M. Avian interspecific differences in VKOR activity and inhibition: insights from amino acid sequence and mRNA expression ratio of VKORC1 and VKORC1L1. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 228: 108635 (2020) DOI: 10.1016/j.cbpc.2019.108635
25. Togao M*, Nakayama SMM* (* Equal contribution), Ikenaka Y, Mizukawa H, Makino Y, Kubota A, Matsukawa T, Yokoyama K, Hirata T, Ishizuka M. Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry. Chemosphere. 238:124581 (2020) DOI: 10.1016/j.chemosphere.2019.124581

▲このページの先頭へ

Original Articles

1. Kodai MOTOHIRA, Yoshinori IKENAKA, Yared Beyene YOHANNES, Shouta M.M. NAKAYAMA, Victor WEPENER, Nico J. SMIT, Johan H.J. VAN VUREN, Ana Catarina SOUSA, Alex Ajeh ENUNEKU, Emmanuel Temiotan OGBOMIDA, Mayumi ISHIZUKA. Dichlorodiphenyltrichloroethane (DDT) levels in rat livers collected from a malaria vector control region. Journal of Veterinary Medical Science. 81: 1575-1579 (2019) DOI: 10.1292/jvms.19-0168
2. 中山翔太、池中良徳、谷川力、石塚真由美、ドブネズミとクマネズミのワルファリン抵抗性と今後の課題、ねずみ情報、No.80：pp1-10 (2019)
3. Tetsushi Hirano, Satsuki Minagawa, Yukihiro Furusawa, Tatsuya Yunoki, Yoshinori Ikenaka, Toshifumi Yokoyama, Nobuhiko Hoshi, and Yoshiaki Tabuchi. Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells. Toxicology and Applied Pharmacology. 383: 114777 (2019) DOI: 10.1016/j.taap.2019.114777
4. Botha TL, Brand SJ, Ikenaka Y, Nakayama SMM, Ishizuka M, Wepener V. How toxic is a non-toxic nanomaterial: Behaviour as an indicator of effect in Danio rerio exposed to nanogold. Aquatic Toxicology. 215: 105287 (2019) DOI: 10.1016/j.aquatox.2019.105287
5. Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Darwish WS, Takiguchi M, Tanabe S, Ishizuka M. Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 226: 108613 (2019) DOI: 10.1016/j.cbpc.2019.108613
6. Thompson LA, Ikenaka Y, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M. Effects of the organochlorine p,p’-DDT on MCF-7 cells: investigating metabolic and immune modulatory transcriptomic changes. Environmental Toxicology and Pharmacology. 72: 103249 (2019) DOI: 10.1016/j.etap.2019.103249
7. Miura R, Araki A, Minatoya M, Miyake K, Chen ML, Kobayashi S, Miyashita C, Yamamoto J, Matsumura T, Ishizuka M, Kubota T, Kishi R. An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A. Scientific Reports. 9:12369 (2019) DOI: 10.1038/s41598-019-48916-5
8. Hiwatari M, Yamada D, Hangoma P, Narita D, Mphuka C, Chitah B, Yabe J, Nakayama SMM, Nakata H, Choongo K, Ishizuka M. Assessing the population-wide exposure to lead pollution in Kabwe, Zambia : blood lead level estimation based on survey data. Faculty of Economics and Business, Hokkaido University, Discussion Paper, Series A 338: 1-28 (2019) http://hdl.handle.net/2115/74300
9. C.M. Volschek, R Gerber, M.T. Mkhonto, Y. Ikenaka, Y.B. Yohannes, S.M. Nakayama, M. Ishizuka, , J.H.J. van Vuren, V. Wepener, NJ. Smit. Bioaccumulation of persistent organic pollutants and their trophic transfer through the food web: Human health risks to the rural communities reliant on fish from South Africa’s largest floodplain. Science of the Total Environment 685: 1116-1126 (2019) DOI: 10.1016/j.scitotenv.2019.06.144
10. Takahashi K, Tsurumi T, Inami M, Li Z, Kusakabe T, Kikkawa S, Azumaya I, Tominaga N, Ikenaka Y, Arizono K, Kato K. Syntheses of 4‐OH and 5‐OH Imidacloprids. Chemistry Select. 4: 7343-7345 (2019) DOI: 10.1002/slct.201901491
11. Go Ichikawa, Ryota Kuribayashi, Yoshinori Ikenaka, Takahiro Ichise, Shouta M. M. Nakayama, Mayumi Ishizuka, Kumiko Taira, Kazutoshi Fujioka, Toshimi Sairenchi, Gen Kobashi, Jean-Marc Bonmatin, Shigemi Yoshihara. LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth. Plos ONE. 14 : e0219208 (2019)DOI: 10.1371/journal.pone.0219208
12. Kohki Takaguchi, Hiroyuki Nishikawa, Hazuki Mizukawa, Rumi Tanoue, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Tatsuya Kunisue, Mayumi Ishizuka, Shinsuke Tanabe, Hisato Iwata, Kei Nomiyama. Effects of PCB exposure on serum thyroid hormone levels in dogs and cats. Science of the Total Environment. 688: 1172-1183 (2019) DOI: 10.1016/j.scitotenv.2019.06.300
13. Nakayama SMM*, Nakata H* (Equal contribution), Ikenaka Y, Yabe J, Oroszlanya B, Yohannes YB, Bortey-Sam N, Muzandu K, Choongo K, Kuritani T, Nakagawa M, Ishizuka M. One year exposure to Cd- and Pb-contaminated soil causes metal accumulation and alteration of global DNA methylation in rats. Environmental Pollution. 252:1267-1276 (2019) DOI: 10.1016/j.envpol.2019.05.038
14. Mwandira W, Nakashima K, Kawasaki S, Ito M, Sato T, Igarashi T, Banda K, Chirwa M, Nyambe I, Hokuto N, Nakayama SMM, Ishizuka M., Solidification of sand by Pb(II)-tolerant bacteria for capping mine waste to control metallic dust: Case of the abandoned Kabwe Mine, Zambia. Chemosphere. 228: 17-25 (2019) DOI; 10.1016/j.chemosphere.2019.04.107
15. H. Bouwman, Y.B. Yohannes, S.M.M. Nakayama, K. Motohira, M. Ishizuka, M.S. Humphries, V. van der Schyff, M. du Preez, A. Dinkelmann, Y. Ikenaka. Evidence of impacts from DDT in pelican, cormorant, stork, and egret eggs from KwaZulu-Natal, South Africa. Chemosphere. 225: 647-658 (2019) DOI: 10.1016/j.chemosphere.2019.03.043
16. Yasuhiro Uno, Rika Takahira, Norie Murayama, Shunsuke Onozeki, Shu Kawamura, Shotaro Uehara, Yoshinori Ikenaka, Mayumi Ishizuka, Shinichi Ikushiro, Hiroshi Yamazaki, Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques. Biochemical Pharmacology, 163 335-344 (2019) DOI: 10.1016/j.bcp.2019.03.002
17. Mwandira W, Nakashima K, Kawasaki S, Ito M, Sato T, Igarashi T, Banda K, Chirwa M, Nyambe I, Nakayama S, Ishizuka M. Efficacy of biocementation of lead mine waste from the Kabwe Mine site evaluated using Pararhodobacter sp.. Environmental Science and Pollution Research. 26(15): 15653-15664 (2019) DOI: 10.1007/s11356-019-04984-8.
18. C.M. Volschek, Y. Ikenaka, Y.B. Yohannes, S.M. Nakayama, M. Ishizuka, E. Smit, J.H.J. van Vuren, R. Greenfield. Baseline bio-accumulation concentrations and resulting oxidative stress in Synodontis zambezensis after an acute laboratory exposure to 4,4’-DDT. Pesticide Biochemistry and Physiology. 156: 44-55 (2019) DOI: 10.1016/j.pestbp.2019.02.005
19. A Shoji, KH Elliott, S Aris‐Brosou, H Mizukawa, SMM Nakayama, Y Ikenaka, M Ishizuka, T Kuwae, K Watanabe, J Escoruela Gonzalez, Y Watanuki. Biotransport of metallic trace elements from marine to terrestrial ecosystems by seabirds. Environmental toxicology and chemistry. 38(1): 106-114 (2019) DOI: 10.1002/etc.4286
20. Nakayama SMM, Morita A, Ikenaka Y, Mizukawa H, Ishizuka M. A review: Poisoning by Anticoagulant Rodenticides in Non-Target Animals Globally. JVMS. 81(2):298-313 (2019) DOI: 10.1292/jvms.17-0717
21. Kawai YK, Shinya So, Ikenaka Y, Saengtienchai A, Kondo T, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M. Characterization of function and genetic feature of UDP-glucuronosyltransferase in avian species. CBP. 217: 5-14 (2019) DOI: 10.1016/j.cbpc.2018.11.001

▲このページの先頭へ

Original Articles

1. Ikenaka Y, Miyabara Y, Ichise T, Nakayama SMM, Nimako C, Ishizuka M, Tohyama C. Exposures of children to neonicotinoids in pine wilt disease control areas. Environ Toxicol Chem. 38(1):71-79 (2018) DOI: 10.1002/etc.4316
2. Ikenaka Y, Fujioka K, Kawakami T, Ichise T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Taira K, Takahashi K, Kato K, Arizono K, Ishizuka M. Contamination by neonicotinoid insecticides and their metabolites in Sri Lankan black tea leaves and Japanese green tea leaves. Toxicology Reports. 5: 744-749 (2018) DOI:10.1016/j.toxrep.2018.06.008
3. Chinzei K, Shimizu A, Mori K, Harada K, Takeda H, Hashizume M, Ishizuka M, Kato N, Kawamori R, Kyo S, Nagata K, Yamane T, Sakuma I, Ohe K, Mitsuishi M. Regulatory Science on AI-based Medical Devices and Systems. Advanced Biomedical Engineering. 7: 118-123 (2018) DOI:10.14326/abe.7.118
4. Gerber R, Smit NJ, van Vuren JHJ, Ikenaka Y, Wepener V. Biomarkers in tigerfish (Hydrocynus vittatus) as indicators of metal and organic pollution in ecologically sensitve subtropical rivers. Ecotoxicol Environ Saf. 157: 307-317 (2018) DOI: 10.1016/j.ecoenv.2018.03.091
5. Ishibashi H, Uchida M, Yoshimoto K, Imamura Y, Yamamoto R, Ikenaka Y, Kawai M, Ichikawa N, Takao Y, Tominaga N, Ishibashi Y, Arizono K. Occurrence and seasonal variation of equine estrogens, equilin and equilenin, in the river water of Japan: Implication with endocrinedisrupting potentials to Japanese medaka (Oryzias latipes). Environmental Pollution. 239: 281-288 (2018) DOI: 10.1016/j.envpol.2018.04.029
6. Yamamoto K, Ikenaka Y, Ichise T, Bo T, Ishizuka M, Yasui H, Hiraoka W, Yamamori T, Inanami O. Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR. Free Radical Research. 52: 648-660 (2018) DOI: 10.1080/10715762.2018.1460472
7. Thompson L.A, Ikenaka Y, Yohannes Y.B, Ichise T, Ito G, Bortey-Sam N, van Vuren J.J, Wepener V, Smit N.J, Darwish W.S, Nakayama S.M.M, Mizukawa H, Ishizuka M. Human Health Risk from Consumption of Marine Fish Contaminated with DDT and its Metabolites in Maputo Bay, Mozambique. BECT. 100:672-676 (2018) DOI: 10.1007/s00128-018-2323-7.
8. Yabe J, Nakayama S.M.M, Ikenaka Y, Yohannes YB, Bortey-Sam N, Kabalo AN, Ntapisha J, Mizukawa H, Umemura T, Ishizuka M. Lead and cadmium excretion in feces and urine of children from polluted townships near a lead-zinc mine in Kabwe, Zambia. Chemosphere. 202: 48-55 (2018) DOI: 10.1016/j.chemosphere.2018.03.079
9. Ishii C, Ikenaka Y, Ichii O, Nakayama SMM, Nishimura S, Ohashi T, Tanaka M, Mizukawa H, Ishizuka M. A glycomics approach to discover novel renal biomarkers in birds by administration of cisplatin and diclofenac to chickens. Poultry Science. pey016 (2018) DOI:10.3382/ps/pey016
10. Pheiffer W, Wolmarans NJ, Gerber R, Yohannes YB, Ikenaka Y, Ishizuka M, Smit NJ, Wepener V, Pieters R. Fish consumption from urban impoundments: What are the health risks associated with DDTs and other organochlorine pesticides in fish to township residents of a major inland city. Sci. Total. Environ. 628-629: 517-527 (2018) DOI: 10.1016/j.scitotenv.2018.02.075
11. Ueno D, Mizukawa H, Inanami O, Nagasaka H, Tatsuta N, Narazaki Y, Fujino T, Watanabe I, Kameda Y, Nakai K. “Caddisfly watch,” a biomonitoring program using Stenopsyche larvae to determine radioactive cesium contamination in rivers following the Fukushima nuclear disaster. Landscape. Ecol. Eng.  14:29–35 (2018) DOI: 10.1007/s11355-017-0333-y
12. Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Asante KA, Baidoo E, Obirikorang C, Mizukawa H, Ishizuka M. Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana. Environ Pollut. 235: 163-170 (2018) DOI: 10.1016/j.envpol.2017.12.005
13. Ogbomida ET, Nakayama SMM, Bortey-Sam N, Oroszlany B, Tongo I, Enuneku AA, Ozekeke O, Ainerua MO, Fasipe IP, Ezemonye LI, Mizukawa H, Ikenaka Y, Ishizuka M. Accumulation Patterns and Risk Assessment of Metals and Metalloid in Muscle and Offal of free-Range Chickens, Cattle and Goat in Benin City. Ecotoxicology and Environmental Safety. 151: 98-108 (2018) DOI: 10.1016/j.ecoenv.2017.12.069
14. Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo JT, Saengtienchai A, Mizukawa H, Ishizuka M. Sex and site differences in urinary excretion of conjugated pyrene metabolites in the West African Shorthorn cattle. JVMS. 80: 375-381 (2018) DOI:10.1292/jvms.17-0410.
15. Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Thompson LA, Ishizuka M. β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line. Environ Sci Pollut Res Int. 25:6320-6328 (2018) DOI:10.1007/s11356-017-0977-z.
16. Ishii C, Nakayama SMM, Kataba A, Ikenaka Y, Saito K, Watanabe Y, Makino Y, Matsukawa T, Kubota A, Yokoyama K, Mizukawa H, Hirata T, Ishizuka M. Characterization and imaging of lead distribution in bones of lead-exposed birds by ICP-MS and LA-ICP-MS. Chemosphere. 212: 994-1001 (2018) DOI: 10.1016/j.chemosphere.2018.08.149
17. Thompson LA, Ikenaka Y, Darwish WS, Yohannes YB, van Vuren JJ, Wepener V, Smit NJ, Assefa AG, Tharwat A, Eldin WFS, Nakayama SMM, Mizukawa H, Ishizuka M. Investigation of mRNA expression changes associated with field exposure to DDTs in chickens from KwaZulu-Natal, South Africa. PLOS ONE. 13(10): e0204400. (2018) DOI: 10.1371/journal.pone.0204400.
18. Saengtienchai A, Ikenaka Y, Kawata M, Kawai Y, Takeda K, Kondo T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Ishizuka M. Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species. CBP. 214: 28-35 (2018) DOI: 10.1016/j.cbpc.2018.08.007
19. Nicolaas Johannes Wolmarans Louis H Du Preez, Ph.D.; Yohannes Y.B, Ikenaka Y, Ishizuka M, Smit N.J, Wepener V. Linking organochlorine exposure to biomarker response patterns in Anurans: a case study of Müller’s clawed frog (Xenopus muelleri) from a tropical malaria vector control region. Ecotoxicology. 27(9): 1203-1216 (2018) DOI: 10.1007/s10646-018-1972-y
20. Uno Y, Takahira R, Murayama N, Ishii Y, Ikenaka Y, Ishizuka M, Yamazaki H, Ikushiro S. Molecular and functional characterization of UDP-glucuronosyltransferase T 1A in cynomolgus macaques. Biochemical Pharmacology. 155: 127-181 (2018) DOI:10.1016/j.bcp.2018.06.027
21. Takeda K, Ikenaka Y, Tanikawa T, Tanaka KD, Nakayama SMM, Mizukawa H, Ishizuka M. Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats (Rattus rattus) in Tokyo by in situ liver perfusion.Pestic Biochem Physiol. 48:42-49 (2018) DOI:10.1016/j.pestbp.2018.03.018
22. Pheiffer W, Bortey-Sam N, Ikenaka Y, Nakayama S.M.M, Mizukawa H, Ishizuka M, Smit NJ, Pieters R. First report of OH-PAHs in South African Clarias gariepinus bile from an urban impacted system. African Journal of Aquatic Science. 43: 307-317 (2018) DOI: 10.2989/16085914.2018.1511408
23. Yusuke K Kawai, Yoshinori Ikenaka, Mayumi Ishizuka, Akira Kubota. The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not. PloS one. 13(10): e0205266 (2018) DOI: 10.1371/journal.pone.0205266
24. Osei Akoto, Nesta Bortey-Sam, Shouta MM Nakayama, Yoshinori Ikenaka, Elvis Baidoo, Joseph Apau, Jemima Tiwaa Marfo, Mayumi Ishizuka. Characterization, Spatial Variation and Risk Assessment of Heavy Metals and a Metalloid in Surface Soils in Obuasi, Ghana. Journal of Health and Pollution. 8(19) (2018) DOI: 10.5696/2156-9614-8.19.180902

▲このページの先頭へ

Original Articles

1. Nomiyama K, Takaguchi K, Mizukawa H, Nagano Y, Oshihoi T, Nakatsu S, Kunisue T, Tanabe S. Species- and Tissue-Specific Profiles of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Derivatives in Cats and Dogs. Environ. Sci. Technol. 51(10): 5811-5819 (2017) DOI: 10.1021/acs.est.7b01262
2. 中山翔太、水川葉月、池中良徳、石塚真由美、鳥類で起こっているケミカルハザードとそのメカニズム、日本野生動物医学会誌、22(4): 69-72 (2017)
3. 石井千尋、中山翔太、水川葉月、池中良徳、石塚真由美、鳥類の鉛中毒の分析と原因、中毒研究、30: 363-367 (2017)
4. Sasaki N, Ishi K, Kudo N, Nakayama SMM, Nakamura K, Morishita K, Ohta H, Ishizuka M, Takiguchi M. Spatial and temporal profile of cisplatin delivery by ultrasound-assisted intravesical chemotherapy in a bladder cancer model. PLOS ONE. 12(11):e0188093 (2017) DOI: 10.1371/journal.pone.0188093.
5. Uchida Y, Banda K, Nyambe I, Hamamoto T, Yoshii Y, Munthali K, Mwansa M, Mukuka M, Mutale M, Yabe J, Toyomaki H, Yohannes YB, Nakayama SMM, Naruse N, Ishizuka M, Takahashi Y. Multidisciplinary field research in Kabwe, Zambia, towards better understanding of lead contamination of the city – A short report from a field survey. bioRxiv (2017) DOI: https://doi.org/10.1101/096164
6. Akoto O, Bortey-Sam N, Ikenaka Y, Nakayama SMM, Baidoo E, Yohannes YB, Ishizuka M. Contamination Levels and Sources of Heavy Metals and a Metalloid in Surface Soils in the Kumasi Metropolis, Ghana. Journal of Health and Pollution. 15: 28-39 (2017)
7. Kondo T, Ikenaka Y, Nakayama SMM, Kawai YK, Mizukawa H, Mitani Y, Nomiyama K, Tanabe S,  Ishizuka M. UDP-glucuronosyltransferase (UGT) 2B subfamily interspecies differences in carnivores. Tox. Sci. 158: 90-100 (2017) DOI: 10.1093/toxsci/kfx072
8. Ishii C,  Nakayama SMM, Ikenaka Y, Nakata H, Saito K, Watanabe Y, Mizukawa H, Tanabe S, Nomiyama K, Hayashi T, Ishizuka M. Lead exposure in raptors from Japan and source identification using Pb stable isotope ratios. Chemosphere. 186: 367-373 (2017) DOI: 10.1016/j.chemosphere.2017.07.143
9. Kobayashi S, Sata F, Miyashita C, Miura R, Azumi K, Kobayashi S, Goudarzi H, Araki A, Ishizuka M, Todaka T, Kajiwara J, Hori T, Kishi R. Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study. Toxicology. 390: 135-145 (2017) DOI: 10.1016/j.tox.2017.08.010
10. Mizukawa H, Nomiyama K, Nakatsu S, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama SMM, Tanabe S. Anthropogenic and Naturally Produced Brominated Phenols in Pet Blood and Pet Food in Japan. Environ. Sci. Technol. 51(19): 11354-11362 (2017) DOI: 10.1021/acs.est.7b01009
11. Yohannes YB, Ikenaka Y, Gengo I, Nakayama SMM, Mizukawa H, Victor Wepener N, Smit NJ, van Vuren JJ, Ishizuka M. Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa. Environmnetal Science and Pollution Research. 24:23763-23770 (2017) DOI: 10.1007/s11356-017-9911-7
12. Thompson LA, Ikenaka Y, Yohannes YB, van Vuren JJ, Wepener V, Smit NJ, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M. Concentrations and Human Health Risk Assessment of DDT and Its Metabolites in Free-range and Commercial Chicken Products from KwaZulu-Natal, South Africa. Food Additives and Contaminants: Part A. 34(11): 1959-1969 (2017) DOI: 10.1080/19440049.2017.1357209
13. M’kandawire E, Choongo K, Yabe J, Mwase M, Saasa N, Nakayama SMM, Bortey-Sam N, Blindauer. Sediment Metal Contamination in the Kafue River of Zambia and Ecological Risk Assessment. Bulletin of Environmental Contamination and Toxicology. 98:172-177 (2017) DOI: 10.3390/ijerph14010056
14. Kobayashi S, Azumi K, Goudarzi H, Araki A, Miyashita C, Kobayashi S, Itoh S, Sasaki S, Ishizuka M, Nakazawa H, Ikeno T, Kishi R. Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido Study. Journal of Exposure Science and Environmental Epidemiology. 27:251-259 (2017) DOI: 10.1038/jes.2016.50
15. 水川葉月、池中良徳、筧麻友、中山翔太、石塚真由美：非実験動物における化学物質代謝能の特徴と種差 Characterization of species differences of xenobiotic metabolism in non-experimental animals. YAKUGAKU ZASSHI 137:257-263（2017）
16. Ishii C, Ikenaka Y, Nakayama SMM, Mizukawa H, Yohannes YB, Watanuki Y, Fukuwaka M, Ishizuka M. Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea. JVMS. 79:807-814 (2017) DOI: 10.1292/jvms.16-0441
17. Thompson LA, Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Organochlorine pesticide contamination of foods in Africa: incidence and public health significance. JVMS. 79:751-764 (2017) DOI: 10.1292/jvms.16-0214
18. Nakata H*, Nakayama SMM*, Oroszlany B, Ikenaka Y, Mizukawa H, Tanaka K, Harunari T, Tanikawa T, Darwish WS, Yohannes YB, Saengtienchai A, Ishizuka M (* Equal contribution). Monitoring lead (Pb) pollution and identifying Pb pollution sources in Japan using stable Pb isotope analysis with kidney of wild rats. Int. J. Environ. Res. Public Health. 14(1):E56 (2017) DOI: 10.3390/ijerph14010056
19. Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Trace Element Contamination in Tissues of Four Bird Species from the Rift Valley Region, Ethiopia. BECT. 98:172-177 (2017) DOI: 10.1007/s00128-016-2011-4
20. Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia. Sci. Total. Environ. 574: 1389-1395 (2017) DOI: 10.1016/j.scitotenv.2016.08.056

▲このページの先頭へ

Original Articles

1. Takeda K*, Ikenaka Y*, Tanikawa T, Tanaka KD, Nakayama SMM, Mizukawa H, Ishizuka M (*Equal contribution). Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis. Pestic Biochem Physiol. 134:1-7 (2016) DOI: 10.1016/j.pestbp.2016.04.004
2. Saengtienchai A, Ikenaka Y, Bortey-Sam N, Jermnark U, Mizukawa H, Kawai YK, Nakayama SMM, Ishizuka M. The African hedgehog (Atelerix albiventris): low phase I and phase II metabolism activities. Comp Biochem Physiol C Pharmacol Toxicol. 190: 38-47 (2016) DOI: 10.1016/j.cbpc.2016.08.005
3. Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo J, Saengtienchai A, Mizukawa H, Ishizuka, M. Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana. Environmental Pollution. 218: 331-337 (2016) DOI: 10.1016/j.envpol.2016.07.008
4. Bortey-Sam N*, Nakayama SMM*, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Heavy metals and metalloid accumulation in livers and kidneys of wild rats around gold-mining communities in Tarkwa, Ghana. Journal of Environmental Chemistry and Ecotoxicology, 8(7), pp.58-68 (2016) DOI: 10.5897/JECE2016.0374
5. Nakayama SMM,  Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M. Characterization of Equine Cytochrome P450: Role of CYP3A in the Metabolism of Diazepam. Journal of Veterinary Pharmacology and Therapeutics.  39(5):478-87 (2016) DOI: 10.1111/jvp.12303
6. Watanuki Y, Yamashita A, Ishizuka M, Ikenaka Y, Nakayama SMM, Ishii C, Yamamoto T, Ito M, Kuwae T, Trathan PN. Feather mercury concentration in streaked shearwaters wintering in separate areas of Southeast Asia. Mar Ecol Prog Ser. 546: 263-269 (2016) DOI: 10.3354/meps11669
7. Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Constitutive Effects of Lead on Aryl Hydrocarbon Receptor Gene Battery and Protection by β-carotene and Ascorbic Acid in Human HepG2 Cells. J. Food. Sci. 81(1):T275-81 (2016) DOI: 10.1111/1750-3841.13162
8. Gerber R, Smit NJ, Van Vuren JH, Nakayama SMM, Yohannes YB, Ikenaka Y, Ishizuka M, Wepener V. Bioaccumulation and human health risk assessment of DDT and other organochlorine pesticides in an apex aquatic predator from a premier conservation area. Sci. Total. Environ. 550: 522-533 (2016) DOI: 10.1016/j.scitotenv.2016.01.129
9. Nishiyama Y, Nakayama SMM, Watanabe KP, Kawai YK, Ohno M, Ikenaka Y, Ishizuka M. Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats. JVMS. 78.4: 675-80 (2016) DOI: 10.1292/jvms.15-0299
10. Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama S, Kunisue T, Tanabe S. Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances? Environ. Sci. Technol. 50(1):444-52 (2016) DOI: 10.1021/acs.est.5b04216
11. Nakata H*, Nakayama SMM*, Yabe J, Liazambi A, Mizukawa H, Darwish WS, Ikenaka Y, Ishizuka M (* Equal contribution). Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens. Environ Pollut. 208(Pt B):395-403 (2016) DOI: 10.1016/j.envpol.2015.10.006
12. Mahmoud AFA, IkenakaY, YohannesYB, DarwishWS, Eldaly EA, Morshdy AE, Nakayama SMM, MizukawaH, Ishizuka M. Distribution and health risk assessment of organochlorine pesticides (OCP) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCP in tongue. Chemosphere 144:1365-71 (2016) DOI: 10.1016/j.chemosphere.2015.10.016
13. Darwish WS, Ikenaka Y, Morshdy AE, Eldesoky KI, Nakayama SMM, MizukawaH, Ishizuka M. β-carotene and retinol contents in the meat of herbivorous ungulates with a special reference to their public health importance. JVMS. 78.2: 351 (2016) DOI: 10.1292/jvms.15-0287

▲このページの先頭へ

Original Articles

1. Yoo J, Hirano M, Mizukawa H, Nomiyama K, Agusa T, Kim E-Y, Tanabe S, Iwata H. In vitro and in silico analyses for predicting hepatic cytochrome P450-dependent metabolic potencies of polychlorinated biphenyls in the Baikal seal.  Environ. Sci. Technol. 49(24):14588-96 (2015) DOI: 10.1021/acs.est.5b03890
2. Marfo JT ^*, Fujioka K^*, Ikenaka Y, Nakayama SMM, Mizukawa H, Aoyama Y, Ishizuka M, Taira K (^*Equal contribution). Relationship between urinary N-desmethyl-acetamiprid and typical symptoms including neurological findings: A prevalence case-control study. PlosONE 10(11):e0142172 (2015) DOI: 10.1371/journal.pone.0142172
3. Teraoka H, Okamoto E, Kudo M, Nakayama SMM, Ikenaka Y, Ishizuka M, Endo T, Kitazawa T, Hiraga T. Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan. Ecotoxicology and Environmental Safety. 122:557-564 (2015) DOI: 10.1016/j.ecoenv.2015.09.025
4. Bortey-Sam N*, Nakayama SMM*, Akoto O, Ikenaka Y, Fobil N.J., Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Ecological Risk of Heavy Metals and a Metalloid in Agricultural Soils in Tarkwa, Ghana. Int J Environ Res Public Health. 12(9):11448-11465 (2015) DOI: 10.3390/ijerph120911448
5. Gerber R, Smit N, van Vuren J, Nakayama SMM, Yohannes YB, Ikenaka Y, Ishizuka M, Wepener V. Application of a Sediment Quality Index for the assessment and monitoring of metals and organochlorines in a premier conservation area. Environ Sci Pollut Res. 22(24):19971-19989 (2015) DOI: 10.1007/s11356-015-5206-z
6. Bortey-Sam N*, Nakayama SMM*, Akoto O, Ikenaka Y, Fobil N.J., Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Accumulation of heavy metals and metalloid from agricultural soils to foodstuffs around Tarkwa area in Ghana, and associated human health risks. Int J Environ Res Public Health. 12(8):8811-8827 (2015) DOI: 10.3390/ijerph120808811
7. Watanabe KP, Kawata M, Ikenaka Y, Nakayama  SMM, Ishii C, Darwish WS, Saengtienchai A, Mizukawa H, Ishizuka M. Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken. Environ Toxicol Chem. 34(10):2328-2334 (2015) DOI: 10.1002/etc.3062
8. Kakehi M, Ikenaka Y, Nakayama  SMM, Kawai YK, Watanabe KP, Mizukawa H, Nomiyama K, Tanabe S, Ishizuka M. Uridine diphosphate-glucuronosyltransferase (UGT) xenobiotic metabolizing activity and genetic evolution in Pinniped species. Tox Sci. 147(2):360-9 (2015) DOI: 10.1093/toxsci/kfv144
9. Bortey-Sam N*, Nakayama  SMM*, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Health risk assessment of heavy metals and metalloid in drinking water from communities near gold mines in Tarkwa, Ghana. Environ Monit Assess, 187(7):1-12 (2015) DOI: 10.1007/s10661-015-4630-3
10. Darwish WS, Nakayama SMM, Itotani Y, Ohno M, Ikenaka Y, Ishizuka M. Metabolic Activation of Heterocyclic Amines and Expression of Xenobiotic-Metabolizing Enzymes in the Gastrointestinal Tract of Rats. J Food Sci, 80(7):T1627-T1632 (2015) DOI: 10.1111/1750-3841.12931
11. Darwish WS, Hussein MA, El-Desoky KI, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M. Incidence and public health risk assessment of toxic metal residues (cadmium and lead) in Egyptian cattle and sheep meats. Int Food Res J, 22(4):1719-1726 (2015)
12. Nakata H*, Nakayama SMM*, Ikenaka Y, Mizukawa H, Ishii C, Yohannes YB, Konnai S, Darwish WS, Ishizuka M (* Equal contribution). Metal extent in blood of livestock from Dandora dumping site, Kenya: source identification of Pb exposure by stable isotope analysis. Environ Pollut. 205:8-15 (2015) DOI: 10.1016/j.envpol.2015.05.003
13. Saengtienchai A, Ikenaka Y, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M. Characterization and tissue distribution of conjugated metabolites of pyrene in the rat. J Vet Med Sci. 77(10):1261-1267 (2015) DOI: 10.1292/jvms.14-0632
14. Ikenaka Y, Nakayama SMM, Oguri M, Saengtienchai A, Mizukawa H, Kobayashi J, Darwish WS, Ishizuka M. Are red gourami (Colisa labiosa) low xenobiotic metabolizers? Elucidation of in vivo pharmacokinetics of pyrene as a model substrate. Environ Toxicol Pharmacol, 39:1148-1153 (2015) DOI: 10.1016/j.etap.2015.04.004
15. Mizukawa H, Nomiyama K, Kunisue T, Watanabe MX, Subramanian A, Iwata H, Ishizuka M, Tanabe S. Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P450. Environ Res, 138:255-263 (2015) DOI: 10.1016/j.envres.2015.02.012
16. Watanuki Y, Yamamoto T, Yamashita A, Ishii C, Ikenaka Y, Nakayama SMM, Ishizuka M, Suzuki Y, Niizuma Y, Meathrel CE, Phillips RA. Mercury concentrations in primary feathers reflect pollutant exposure in discrete non-breeding grounds used by Short-tailed Shearwaters. Journal of Ornithology, 156:847-850 (2015) DOI: 10.1007/s10336-015-1205-6
17. Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama M.M.S, Yared YB, Baidoo E, Mizukawa H, Ishizuka M. Levels, potential sources and human health risk of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in Kumasi-Ghana. Environ Sci Pollut Res, Jul;22(13):9658-67 (2015) DOI: 10.1007/s11356-014-4022-1
18. Yabe J*, Nakayama SMM*, Ikenaka Y, Yohannes YB, Bortey-Sam N, Oroszlany B, Muzandu K, Choongo K, Kabalo AN, Ntapisha J, Mweene A, Umemura T, Ishizuka M (* Equal contribution). Lead poisoning in children from townships in the vicinity of a lead-zinc mine in Kabwe, Zambia. Chemosphere, 119:941-947 (2015) DOI: 10.1016/j.chemosphere.2014.09.028
19. Bortey-Sam N*, Nakayama SMM*, Ikenaka Y, Akoto O, Yohannes YB, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution). Human health risks from metals and metalloid via consumption of food animals near Gold Mines in Tarkwa, Ghana: Estimation of the daily intakes and target hazard quotients (THQs). Ecotoxicology and Environmental Safety, 111:160-167 (2015) DOI: 10.1016/j.ecoenv.2014.09.008
20. Watanabe KP, Kawai YK, Nakayama SMM, Ikenaka Y, Mizukawa H, Takaesu N, Ito M, Ikushiro S, Sakaki T, Ishizuka M. Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species. Journal of Veterinary Pharmacology and Therapeutics, 38(2):190-195 (2015) DOI: 10.1111/jvp.12159

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Original Articles

1. Saengtienchai A, Ikenaka Y, Nakayama SMM, Mizukawa H, Kakehi M, Bortey-Sam N, Darwish W, Tsubota T, Terasaki M, Poapolathep A, Ishizuka M. Identification of inter-specific differences in phase II reactions: Determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene. Environmental Toxicology and Chemistry, 33(9):2062-2069 (2014) DOI: 10.1002/etc.2656
2. Sutjarit S, Nakayama SMM, Ikenaka Y, Ishizuka M, Banlunara W, Rerkamnuaychoke W, Kumagai S, Poapolathep A. Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice. Toxicology Letters, 229: 292-302 (2014) DOI: 10.1016/j.toxlet.2014.06.843
3. Ishii C, Ikenaka Y, Nakayama SMM, Suzuki Y, Watanuki Y, Watanabe Y, Yohannes YB, Mizukawa H, Ishizuka M. Contamination status and accumulation characteristics of metals and a metalloid in birds on Teuri Island, Hokkaido, Japan. The Japanese Journal of Veterinary Research, Volume 62, Number 3, 143-149 (2014) DOI: 10.14943/jjvr.62.3.143
4. Fujisawa N, Nakayama SMM, Ikenaka Y, Ishizuka M. TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398. Arch. Toxicol, 88(9):1739-1748 (2014) DOI: 10.1007/s00204-014-1225-7
5. Bortey-Sam N, Ikenaka Y, Nakayama SMM, Akoto O, Yohannes YB, Baidoo E, Mizukawa H, Ishizuka M. Occurrence, distribution, sources and toxic potential of polycyclic aromatic hydrocarbons (PAHs) in surface soils from the Kumasi Metropolis, Ghana. Sci Total Environ, 496:471-478 (2014) DOI: 10.1016/j.scitotenv.2014.07.071
6. Mizukawa H, Ikenaka Y, Nakayama SMM, Sakamoto KQ, Fujita S, Ishizuka M. Contamination status and possibility of toxic effects of co-planar polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dichlorodiphenyltrichloroethane in large Japanese field mouse (Apodemus speciosus) collected from Hokkaido and Aomori. The Japanese Journal of Veterinary Research. Volume 62, Number 3, 107-115 (2014) DOI: 10.14943/jjvr.62.3.107
7. Yohannes YB, Ikenaka Y, Nakamyama SMM, Ishizuka M. Organochlorine pesticides in bird species and their prey (fish) from the Ethiopian Rift Valley region, Ethiopia. Environmental Pollution 192：121-128 (2014) DOI: 10.1016/j.envpol.2014.05.007
8. Yohannes YB, Ikenaka Y, Saengtienchai A, Watanabe KP, Nakamyama SMM, Ishizuka M. Concentrations and human health risk assessment of organochlorine pesticides in edible fish species from a Rift Valley Lake – Lake Ziway, Ethiopia. Ecotoxicol. Environ. Saf. 106:95-101 (2014) DOI: 10.1016/j.ecoenv.2014.04.014
9. Yasui H, Takeuchi R, Nagane M, Meike S, Nakamura Y, Yamamori T, Ikenaka Y, Kon Y, Murotani H, Oishi M, Nagasaki Y, Inanami O. Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles. Cancer Letters 347:151-158 (2014) DOI: 10.1016/j.canlet.2014.02.005
10. Akoto O, Bortey-Sam N, Nakayama SMM, Ikenaka Y, Baidoo E, Yohannes YB, Mizukawa H, Ishizuka M. Distribution of heavy metals in organs of sheep and goat reared in Obuasi: A gold mining town in Ghana. Int. J. Environ. Sci. Toxic. 2:81-89 (2014)
11. M’kandawire E, Syakalima M, Muzandu K, Pandey G, Simuunza M, Nakayama SMM, Kawai YK, Ikenaka Y, Ishizuka M. Molecular characterization and mRNA expression of cytochrome P450 1A1 and cytochrome P450 3A in liver of Kafue Lechwe (Kobus leche kafuensis) as potential biomarkers of pollution of the Kafue River basin, Zambia. Engineering 6:51-58 (2014) DOI: 10.4236/eng.2014.62008
12. Darwish WS, Ikenaka Y, Nakayama SMM, Ishizuka M. The effect of copper on the mRNA expression profile of xenobiotic-metabolizing enzymes in cultured rat H4-II-E cells. Biol. Trace Elem. Res. 158:243-248 (2014) DOI: 10.1007/s12011-014-9915-9
13. Darwish WS, Ikenaka Y, Nakayama SMM, Ishizuka M. An overview on mycotoxin contamination of foods in Africa. J. Vet. Med. Sci. 76:789-797 (2014) DOI: 10.1292/jvms.13-0563
14. Saengtienchai T, Poapolathep S, Isariyodom S, Ikenaka Y, Ishizuka M, Poapolathep A. Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets. Food Chem Toxicol. 66C:307-312 (2014) DOI: 10.1016/j.fct.2014.01.053
15. Shimamoto Y, Watanabe K, Ikadai H, Okamura M, Ishizuka M. Repression of hepatic cytochrome P450 2D expression in mice during Babesia microti infection. J. Vet. Med. Sci. 76(8):1147-1151 (2014) DOI: 10.1292/jvms.14-0109

▲このページの先頭へ

Original Articles

1. Ibrahim ZS, Ahmed MM, Shukry M, Mahmoud S, Ishizuka M. Constitutive androstane receptor dependent and independent modulation of CYP3A2, CYP1A2 by phenobarbital and fibrate in rats’ liver. Am. J. Biochem. Biotech 9:272-281(2013) DOI: 10.3844/ajbbsp.2013.272.281
2. Kitamura H, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, Miyoshi I. Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. FASEB J. 27(12):4940-4953 (2013) DOI: 10.1096/fj.13-233528
3. Watanabe KP, Kawai YK, Ikenaka Y, Kawata M, Ikushiro S, Sakaki T, Ishizuka M. Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver. PLOS ONE e75689(2013) DOI: 10.1371/journal.pone.0075689
4. Fujisawa N, Kawai YK, Nakayama SMM, Ikenaka Y, Yamamoto H, Ishizuka M. Dioxin sensitivity-related two critical amino acids of arylhydrocarbon receptor may not correlate with the taxonomy or phylogeny in avian species. J Vet Med Sci 75:1577-1583 (2013) DOI: 10.1292/jvms.13-0179
5. Sasaki N, Matumoto T, Ikenaka Y, Nakayama SMM, Ishizuka M, Kazusaka A, Fujita S. Repeated treatment with furazolidone induces multiple cytochrome P450-related activities in chicken liver but not in rat liver. J Vet Med Sci 75:1497-1502 (2013) DOI: 10.1292/jvms.12-0531
6. Shimamoto Y, Kitamura H, Niimi K, Yoshikawa Y, Hoshi F, Ishizuka M, Takahashi E. Selection of suitable reference genes for mRNA quantification studies using common marmoset tissues. Molecular Biology Reports 40(12):6747-6755 (2013) DOI: 10.1007/s11033-013-2791-0
7. Ikenaka Y, Oguri M, Saengtienchai A, Nakayama SMM, Ijiri S, Ishizuka M. Characterization of Phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: unique pyrene metabolism and species specificity observed in fish species. Environmental Toxicology and Pharmacology 36:567-578 (2013) DOI: 10.1016/j.etap.2013.05.018
8. Kawai YK, Watanabe KP, Ishii A, Onuma A, Sawa H, Ikenaka Y, Ishizuka M. De novo sequence analysis of cytochrome P450 1–3 genes expressed in ostrich liver with highest expression of CYP2G19. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 8(3):201-208 (2013) DOI: 10.1016/j.cbd.2013.05.002
9. Yohannes YB, Ikenaka Y, Saengtienchai A, Watanabe KP, Nakamyama SMM, Ishizuka M. Occurrence, distribution and ecological risk assessment of DDTs and heavy metals in surface sediments from Lake Awassa – Ethiopian Rift Valley Lake. Environ Sci Pollut Res 20:8663–8671 (2013) DOI: 10.1007/s11356-013-1821-8
10. Fujisawa N, Darwish WS , Ikenaka Y, Kim E, Lee J,Iwata H, Nakayama SMM, Ishizuka M. Molecular evaluation of a new highly sensitive aryl hydrocarbon receptor in ostriches. Poultry Science  92(7):1921-1929 (2013) DOI: 10.3382/ps.2013-03090
11. Yared BY, Ikenaka Y, Nakayama SMM, Saengtienchai A, Watanabe K,　Ishizuka M, Organochlorine pesticides and heavy metals in fish from Lake Awassa; Ethiopia: Insights from stable isotope analysis. Chemosphere 91:857-863 (2013) DOI: 10.1016/j.chemosphere.2013.01.047
12. Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Yabe J, Umemura T, Ishizuka M. Accumulation and biological effects of metals in wild rats in mining areas of Zambia. Environmental Monitoring and Assessment 185:4907-4918 (2013) DOI: 10.1007/s10661-012-2912-6
13. Tanaka KD, Kawai YK, Ikenaka Y, Harunari T, Tanikawa T, Fujita S, Ishizuka M. A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats. J Vet Med Sci. 75(2):135-139 (2013) DOI: 10.1292/jvms.12-0161
14. Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Choongo K, Mainda G, Kabeta N, Ishizuka M, Umemura T. Metal distribution in tissues of free-range chickens near a lead-zinc mine in Kabwe, Zambia. Environ Toxicol Chem. 32(1):189-192 (2013) DOI: 10.1002/etc.2029
15. Nakayama SMM*, Ikenaka Y*, Muzandu K, Choongo K, Yabe J, Muroya T, Ijiri S, Minagawa M, Umemura T, Ishizuka M. GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis spp. from both field and laboratory studies. Arch Environ Contam Toxicol. 64(1):119-129 (2013) (* equal contribution) DOI: 10.1007/s00244-012-9802-3
16. Ikenaka Y, Sakamoto M, Nagata T, Takahashi H, Miyabara Y, Hanazato T, Ishizuka M, Isobe T, Kim JW, Chang KH. Effects of polycyclic aromatic hydrocarbons (PAHs) on an aquatic ecosystem: acute toxicity and community-level toxic impact tests of benzo[a]pyrene using lake zooplankton community. J. Toxicol. Sci. 38(1):131-136 (2013) DOI: 10.2131/jts.38.131

Others

1. Nakayama S.M.M, Ikenaka Y, Muzandu K, Choongo K, Yabe J, Umemura T, Ishizuka M. Metal contaminated soil from mining area caused metal accumulation and biological responses in rats. JJVR, 61:S77-S79 (2013)
2. Hayami A, Darwish W.S, Ikenaka Y, Nakayama S.M.M, Ishizuka M. In vitro diazepam metabolism in horses. JJVR, 61:S80-S82 (2013)
3. Darwish W.S, Eldaly E.A, EL-Abbasy M.T, Ikenaka Y, Nakayama S.M.M, Ishizuka M. Antibiotic residues in food: the African scenario. JJVR, 61:S1-S10 (2013)
4. Darwish W.S, Ikenaka Y, Ishizuka M. Biological responses of xenobiotics metabolizing enzymes to lead exposure in cultured H4IIE rat cells. JJVR, 61:S48-S53 (2013)
5. Oroszlany B, Ikenaka Y, Saengtienchai A, Oguri M, Nakayama S.M.M, Ishizuka M. Metabolism of pyrene, a polycyclic aromatic hydrocarbon in freshwater turtles. JJVR, 61:S62-S63 (2013)
6. Bortey-Sam N, Akoto O, Ikenaka Y, Nakayama S.M.M, Ishizuka M. Determination of benzo[a]pyrene levels in ambient air and the source of polycyclic aromatic hydrocarbons using a diagnostic ratio method in Ghana. JJVR, 61:S64-S66 (2013)
7. Ishii C, Ikenaka Y, Nakayama S.M.M, Suzuki Y, Watanuki Y, Watanabe Y, Fukuwaka M, Yohannes Y.B, Kawai Y.K, Ishizuka M. Heavy metal pollution in Japanese seabirds. JJVR, 61:S67-S69 (2013)
8. Marfo J.T, Akoto O, Nakayama S.M.M, Baidoo E, Ikenaka Y, Ishizuka M. Distribution of metals in organs of Clarias gariepinus, Heterobranchus bidorsalis, and Chrysichthys nigrodigitatus from the Offin River at Dunkwa-on-Offin, Ghana. JJVR, 61:S70-S72 (2013)
9. Mahmoud A.F.A, Darwish W.S, Morshdy A.E.M.A, Eldaly E.A, Ikenaka Y, Ishizuka M. Determination of organochlorine pesticides (OCPs) in the edible offal of Egyptian buffalo. JJVR, 61:S58-S63 (2013)

▲このページの先頭へ

Original Articles

1. Mureithi D, Darwish WS, Ikenaka Y, Kanja L, Ishizuka M. Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts. Jpn. J. Vet. Res. 60(4):205-10(2012) DOI: 10.14943/jjvr.60.4.205
2. Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T. Accumulation of metals in the liver and kidneys of cattle from agricultural areas in Lusaka, Zambia. J Vet Med Sci. 74(10):1345-7(2012) DOI: 10.1292/jvms.12-0142
3. M’kandawire E, Syakalima M, Muzandu K, Pandey G, Simuunza M, Nakayama SMM, Kawai YK, Ikenaka Y, Ishizuka M. The nucleotide sequence of metallothioneins (MT) in liver of the Kafue lechwe (Kobus leche kafuensis) and their potential as biomarkers of heavy metal pollution of the Kafue River. Gene. 506(2):310-6(2012) DOI: 10.1016/j.gene.2012.07.002
4. Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M. Effects of environmental lead contamination on cattle in a lead/zinc mining area: changes in cattle immune systems on exposure to lead in vivo and in vitro. Environ Toxicol Chem. 31(10):2300-5(2012) DOI: 10.1002/etc.1951
5. Okagawa T, Konnai S, Mekata H, Githaka N, Suzuki S, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K. Transcriptional profiling of inflammatory cytokine genes in African buffaloes (Syncerus caffer) infected with Theileria parva. Vet Immunol Immunopathol. 148(3-4):373-9(2012) DOI: 10.1016/j.vetimm.2012.06.015
6. Tanaka KD, Kawai Y, Ikenaka Y, Harunari T, Tanikawa T, Ando S, Min HW, Okajima F, Fujita S, Ishizuka M. The genetic mechanisms of warfarin resistance in Rattus rattus found in the wild in Japan. Pestic Biochem Physiol. 103(2)144-151 DOI: 10.1016/j.pestbp.2012.04.011
7. Nakayama SMM, Ikenaka Y, Muzandu K, Choongo K, M’kandawire E, Yasuda J, Ishizuka M. Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia. Ecotoxicol Environ Saf. 80:333-8(2012) DOI: 10.1016/j.ecoenv.2012.04.003
8. Suzuki S, Konnai S, Okagawa T, Githaka NW, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K. Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer). Int J Immunogenet. 39(2):170-82(2012) DOI: 10.1111/j.1744-313X.2011.01062.x
9. Uno T, Ishizuka M, Itakura T. Cytochrome P450 (CYP) in fish. Environ Toxicol Pharmacol. 34(1):1-13(2012) DOI: 10.1016/j.etap.2012.02.004
10. Kawamoto K, Otsuguro K, Ishizuka M, Ito S. Inhibitory effects of dopamine on spinal synaptic transmission via D1-like receptors in neonatal rats. Br J Pharmacol. 166(2):788-800(2012) DOI: 10.1111/j.1476-5381.2011.01815.x
11. Shimamoto Y, Sasaki M, Ikadai H, Ishizuka M, Yokoyama N, Igarashi I, Hoshi F, Kitamura H. Down-Regulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti. J Vet Med Sci. 74(2):241-5(2012) DOI: 10.1292/jvms.11-0036
12. Ohno M, Ikenaka Y, Ishizuka M. All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells. Biochem Biophys Res Commun. 417:484–489(2012) DOI: 10.1016/j.bbrc.2011.11.146
13. Ohno M, Ikenaka Y, Ishizuka M. Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells. J Biochem Mol Toxicol. 26(1):16-22(2012) DOI: 10.1002/jbt.20408
14. Fujisawa N, Ikenaka Y, Kim EY, Lee JS, Iwata H, Ishizuka M. Molecular Evidence Predicts Aryl Hydrocarbon Receptor Ligand Insensitivity in the Peregrine Falcon (Falco peregrines). Eur. J. Wildlife. Res. 58:167–175(2012)

Others

1. Tanikawa T, Ishizuka M. Urban environment and commensal rodent. Urban Pest Management. 2(2):141-147(2012)

▲このページの先頭へ

Original Articles

1. 池中良徳、石塚真由美.　野生動物の化学物質感受性と生体防御機構.　安全工学50(2): 80
2. Ueda H, Ikenaka Y, Nakayama SM, Tanaka-Ueno T, Ishizuka M. Phase-II conjugation ability for PAH metabolism in amphibians: Characteristics and inter-species differences. Aquat Toxicol. 105(3-4):337-343(2011) DOI: 10.1016/j.aquatox.2011.07.004
3. Saengtienchai A, Ikenaka Y, Watanabe K, Ishida T, Ishizuka M. Comparative Metabolism of Warfarin in Rats and Chickens. Poult Sci. 90:2775-2781(2011) DOI: 10.3382/ps.2010-01257
4. Ohno M, Darwish WS, Ikenaka Y, Miki W, Fujita S, Ishizuka M. Astaxanthin rich crude extract of Haematococcus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cells. Food Chem. 130:356-361(2011) DOI: 10.1016/j.foodchem.2011.07.050
5. Ohno M, Ikenaka Y, Ishizuka M. Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells. J Biochem Mol Toxicol. 26(1):16-22(2012) DOI: 10.1002/jbt.20408
6. Yabe J, Nakayama SM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T. Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia. Environ Toxicol Chem. 30(8):1892-7(2011) DOI: 10.1002/etc.580
7. Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M. Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia.Environmental Pollution 159 175-81(2011)
8. Sasaki N, Matsumoto T, Ikenaka Y, Kazusaka A, Ishizuka M, Fujita S. Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens. Pestic.Biochem. Physiol., 100: 135-139(2011)
9. Ohno M, Darwish WS, Miki W, Ikenaka Y, Ishizuka M. Astaxanthin can alter CYP1A-dependent activities via two different mechanisms: induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer. Food Chem Toxicol., 49: 1285-1291(2011)

▲このページの先頭へ

Original Articles

1. Ikenaka Y, Nakayama SMM, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M. Heavy metal contamination of soil and sediment in Zambia. African Journal of Environmental Science and Technology 4(11):729-739. DOI: 10.4314/ajest.v4i11.71339
2. Darwish WS, Ikenaka Y, Ohno M, Eldaly E. A, Ishizuka M. Carotenoids as regulators for inter-species difference in Cytochrome P450 1A expression and activity in ungulates and rats. Food and Chemical Toxicology. 48: 3201-8. DOI: 10.1016/j.fct.2010.08.022
3. Chang HS, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O. Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. Nutr. Res., 30: 435-440. DOI: 10.1016/j.nutres.2010.06.007
4. Darwish WS, Ikenaka Y, Eldaly E. A, Ishizuka M. Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animals. Food Chem. Toxicol., 48: 2526-2531. DOI: 10.1016/j.fct.2010.06.026
5. Yabe J, Ishizuka M, Umemura T. Current levels of heavy metal pollution in Africa. J Vet Med Sci. 2010 Oct;72(10):1257-63. DOI: 10.1292/jvms.10-0058
6. Darwish WS, Ikenaka Y, El-Ghareeb WR, Ishizuka M. High expression of the mRNA of cytochrome P450 and phase II enzymes in the lung and kidney tissues of cattle. Animal 4(12):2023-2029(2010) DOI: 10.1017/S1751731110001394
7. Kawai YK, Ikenaka Y, Fujita S, Ishizuka M. The CYP1D subfamily of genes in mammals and other vertebrates. Mamm Genome. 21(5-6):320-9(2010) DOI: 10.1007/s00335-010-9263-9
8. Darwish WS, Kawai Y, Ikenaka Y, Yamamoto H, Muroya T, Ishizuka M. Identification and phylogenetic analysis of novel cytochrome P450 1A genes from ungulate species. J Vet Med Sci. 72(9):1237-1241(2010) DOI: 10.1292/jvms.10-0019
9. Watanabe KP, Saengtienchai A, Tanaka KD, Ikenaka Y, Ishizuka M. Comparison of warfarin sensitivity between rat and bird species. Comp Biochem Physiol C Toxicol Pharmacol. 152(1):114-9(2010) DOI: 10.1016/j.cbpc.2010.03.006
10. Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M. Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue. Toxicol. Sci. 116(1):79-91(2010) DOI: 10.1093/toxsci/kfq087
11. Nakayama MMS, Ikenaka Y, Muzandu K, Choongo K, Oroszlany B, Teraoka H, Mizuno N, Ishizuka M. Heavy metal accumulation in lake sediments, fish (Oreochromis niloticus and Serranochromis thumbergi) and crayfish (Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia. Arch Environ Contam Toxicol. 59(2):291-300(2010) DOI: 10.1007/s00244-010-9483-8
12. Darwish WS, Ikenaka Y, Eldaly EA, Ohno M, Sakamoto KQ, Fujita S, Ishizuka M. Cytochrome P450 1A dependent activities in deer, cattle, and horses. J Vet Med Sci. 72(5):561-6(2010) DOI: 10.1292/jvms.09-0318
13. Sata F. Kurahashi N. Ban S. Moriya K. Tanaka KD. Ishizuka M. Nakao H. Yahata Y. Imai H. Kakizaki H. Nonomura K. Kishi R. Genetic polymorphisms of 17β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias. J. Sex. Med. 7: 2729-2738 DOI: 10.1111/j.1743-6109.2009.01641.x
14. Darwish WS, Morshdy AE, Ikenaka Y, Ibrahim ZS, Fujita S, Ishizuka M. Expression and Sequence of CYP1A in Camel. J Vet Med Sci. 72(2):221-4(2010) DOI: 10.1292/jvms.09-0319
15. Kim HS, Sakai N, Saito K, Fujita S, Ishizuka M. Diazepam metabolism in kidney of male and female rats of varying strain. J Vet Med Sci. 72(1):7-11(2010) DOI: 10.1292/jvms.09-0127
16. Sakamoto QK, Sato K, Kato A, Fukui D, Bando G, Naito Y, Habara Y, Ishizuka M, Fujita S. Metabolic alkalosis due to feeding chicks in breeding Adélie penguins Pygoscelis adeliae under natural conditions. Physiological and Biochemical Zoology. 83(2):232-238(2010) DOI: 10.1086/597517

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Original Articles

1. Tanaka K, Harunari T, Tanikawa T, Ikenaka Y, Ishizuka M. Warfarin-resistant of rats in Japan. Jpn. J. Environ. Toxicol. 12(2):61-70(2009) DOI: 10.11403/jset.12.61
2. Sakai N, IshizukaM. Impact of rat P450 genetic polymorphism on diazepam metabolism. Expert Opinion On Drug Metabolism and Toxicology. 5(11):1421-33(2009) DOI: 10.1517/17425250903207002
3. El Bohi KM, Hashimoto Y, Muzandu K, Ikenaka Y, Ibrahim ZS, Kazusaka A, Fujita S, Ishizuka M. Protective effect of Pleurotus cornucopiae mushroom on carbon tetrachloride-induced hepatotoxicity. Jpn J Vet Res. 57(2):109-18(2009)
4. Nakayama SMM, Tanaka-Ueno T, Sakamoto QK, Fujita S, Ishizuka M. Molecular cloning of novel cytochrome P450 1A genes from nine Japanese amphibian species. J Vet Med Sci. 71(10):1407-11(2009) DOI: 10.1292/jvms.001407
5. Sakai N, Sakamoto KQ, Fujita S, Ishizuka M. The importance of heterogeneous nuclear ribonucleoprotein K on Cytochrome P450 2D2 gene regulation: its binding is reduced in Dark Agouti rats. Drug Metab Dispos. 37(8):1703-10(2009) DOI: 10.1124/dmd.109.027284
6. Sakamoto KQ, Sato K, Ishizuka M, Watanuki Y, Takahashi A, Daunt F, Wanless S. Can ethogram be automatically generated using bodyacceleration data from free-ranging birds? PLoS ONE. 4(4):e5379(2009) DOI: 10.1371/journal.pone.0005379
7. Ohno M, Sakamoto KQ, Ishizuka M, Fujita S. Crude cacao Theobroma cacao extract reduces mutagenicity induced by benzo[a]pyrene through inhibition of CYP1A activity in vitro. Phytotherapy Research. 23(8):1134-9(2009) DOI: 10.1002/ptr.2762
8. Sakai N, Saito K, Sakamoto QK, Ishizuka M, Fujita S. Genetic bases basis of inter- and intra-strain differences in diazepam p-hydroxylation in rats. Drug Metab Dispos. 37(2):268-71(2009) DOI: 10.1124/dmd.108.024273
9. Nakano K, Ishizuka M, Sakamoto QK, Fujita S Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate. Biometals 22(2):345-51(2009) DOI: 10.1007/s10534-008-9171-6
10. Sakamoto QK, Sato K, Naito Y, Habara Y, Ishizuka M, Fujita S. Morphological features and blood parameters of Weddell seal (Leptonychotes weddellii) mother and pup during breeding season. J Vet Med Sci. Mar;71(3):341-4(2009) DOI:

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Original Articles

1. Rahman MH, Sakamoto KQ, Nonaka L, Suzuki S. Occurrence anddiversity of
   tetracycline resistance gene tet(M) in enteric bacteria of Antarctic Adélie penguin.
   J Antimicrob Chemother. 62(3):627-8(2008)
2. Ibrahim SZ, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy MA, Sakamoto QK, Fujita S. Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 56(3):119-28(2008)
3. Moustafa GG, Ibrahim ZS, Ahmed MM, Ghoneim MH, Sakamoto KQ, *Ishizuka M, Fujita S. Downregulation of male-specific cytochrome P450 by profenofos. Jpn J Vet Res. 56(2):109-18(2008)
4. Ishizuka M, Tanikawa T, Tanaka KD, Heewon M, Okajima F, Sakamoto KQ, Fujita S. Pesticide resistance in wild mammals–mechanisms of anticoagulant resistance in wild rodents. J Toxicol Sci. 33(3):283-91(2008)
5. Ishizuka M, Fujioka K, Shibamoto T. Analysis of acrylamide in a complex matrix of polyacrylamide solutions treated by heat and ultraviolet light. J Agric Food Chem. 56(15):6093-6(2008)
6. Refat NA, Ibrahim ZS, Moustafa GG, Sakamoto KQ, *Ishizuka M, Fujita S.
   The induction of cytochrome P450 1A1 by sudan dyes. J Biochem Mol Toxicol. 22(2):77-84(2008)
7. Sasaki N, Sakai N, Ikenaka Y, Kamiya T, Heewon M, Sakamoto KQ, *Ishizuka M, Fujita S.
   Antibiotic furazolidone induces CYP1A but not CYP2E1 subfamily in rat liver. J Vet Med Sci. 70(3):223-6(2008)
8. Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R.
   Adverse birth outcomes associated with maternal smoking and polymorphisms
   in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1.Am J Epidemiol. 167(6):719-26(2008)

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Original Articles

1. Ban S, Kondo T, Ishizuka M, Sasaki S, Konishi K, Washino N, Fujita S, Kishi R. Using microarray analysis to evaluate genetic polymorphisms involved in the metabolism of environmental chemicals. Fukuoka Igaku Zasshi. 98(5):208-14(2007)
2. Kim HS, Ishizuka M, Kazusaka A, Fujita S. Di-(2-ethylhexyl)phthalate suppresses tamoxifen-induced apoptosis in GH3 pituitary cells. Arch. Toxicol. 81:27-33(2007)
3. Moustafa GG, Ibrahim ZS, Hashimoto Y, Alkelch AM, Sakamoto KQ, Ishizuka M, Fujita S.
   Testicular toxicity of profenofos in matured male rats. Arch Toxicol. 81(12):875-81(2007)
4. Ishizuka M, Okajima F, Tanikawa T, Min H, Tanaka KD, Sakamoto KQ, Fujita S. Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo. Drug Metab Dispos. 35(1):62-6(2007)
5. Ishizuka M, Nagai S, Sakamoto KQ, Fujita S. Plasma pharmacokinetics and CYP3A12-dependent metabolism of c-kit inhibitor imatinib in dogs. Xenobiotica. 37(5):503-13(2007)
6. Sasaki S, Kondo T, Sata F, Saijo Y, Katoh S, Nakajima S, Ishizuka M, Fujita S and Kishi R．
   Maternal smoking during pregnancy and genetic polymnobiotica. 37(5):503-13(2007)

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Original Articles

1. Jinno A, Maruyama Y, Ishizuka M, Kazusaka A, Nakamura A, and Fujita S． Induction of cytochrome P450‐１A by the equine estrogen equilenin, a new endogenous aryl hydrocarbon receptor ligand. J. Steroid. Biochem. Mol Biol . , 98：48‐55(2006)
2. Ishizuka M, Lee JJ, Masuda M, Akahori F, Kazusaka A, and Fujita S． CYP２D-related metabolism in animals of the Canoidea superfamily-species differences. Vet. Res. Commun.,30：505‐512(2006)
3. Sasaki S, Kondo T, Sata F, Saijo Y, Katoh S, Nakajima S, Ishizuka M, Fujita S, and Kishi R．

   Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP１A１ and GSTM１ affect infant birth size inJapanese subjects. Mol. Hum. Reprod., 12：77‐83(2006)

4. Tanikawa T, Ishizuka M, and Fujita S． Effectiveness of difethialone baits to warfarin-resistant and susceptible colonies on roof rats, Rattus rattus. Medical Entomology and Zoology.,57：355‐359(2006)
5. Muzandu K, Ishizuka M, Sakamoto K Q, Shaban Z, El Bohi K, Kazusaka A, and Fujita S． Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications . Toxicol . Appl . Pharmacol.,215：330‐340(2006)

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Original Articles

1. Sakai N, Saito K, Kim HS, Kazusaka A, Ishizuka M, Funae Y, and Fujita S．
   Importance of CYP２D３ in polymorphism of diazepam p-hydroxylation in rats. Drug Metab, Dispos.,33（１１）：1657 ‐60(2005)
2. Muzandu K, Shaban Z, Ishizuka M, Kazusaka A, and Fujita S．
   Nitric oxide enhances catechol estrogen-induced oxidative stress in LNCaP cells . Free Radic Res.，39（４）：389‐98(2005)
3. Nikaidou S, Ishizuka M, Maeda Y, Hara Y, Kazusaka A, and Fujita S． Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens. Jpn. J. Vet. Res.， 52（４）：185‐92(2005)
4. Muzandu K, El Bohi K, Shaban Z, Ishizuka M, Kazusaka A, and Fujita S． Lycopene and beta-carotene ameliorate catechol estrogen-mediated DNA damage. Jpn. J. Vet. Res.，５２（４）：173‐84(2005)
5. El Bohi KM, Sabik L, Muzandu K, Shaban Z, Soliman M, Ishizuka M, Kazusaka A, and Fujita S．
   Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA98elicited by
   benzo ［a］pyrene and oxidative DNA lesions in V79hamster lung cells . Jpn . J. Vet . Res.，52（4）：163‐72(2005)
6. Shaban Z, Soliman M, El-Shazly S, El-Bohi K, Abdelazeez A, Kehelo K, Kim H S, Muzandu K, Ishizuka M, Kazusaka A, and Fujita S． AhR and PPARalpha : antagonistic effects on CYP２B and CYP３A, and additive inhibitory effects on CYP2C11．Xenobiotica. ，35（１）：51‐68(2005)
7. Nikaidou S, Ishizuka M, Maeda Y, Hara Y, Kazusaka A, and Fujita S． Effect of catechins on mutagenesis of Salmonella typhimurium TA102 elicited by tert-butyl hydroperoxide（t-BuOOH）．J. Vet. Med. Sci.，67（１）：137‐8(2005)

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Original Articles

1. Shaban Z, El-Shazly S, Abdelhady S, Fattouh I, Muzandu K, Ishizuka M, Kimura K, Kazusaka A, Fujita S. Down regulation of hepatic PPARalpha function by AhR ligand. J. Vet. Med. Sci. 66 :1377-1386(2004)
2. Sakamoto KQ, Ishizuka M, Kazusaka A, Fujita S. Iodine intake as a possible cause of discontinuous decline in sperm counts: a re-evaluation of historical and geographic variation in semen quality. Jpn. J. Vet. Res. 52 : 85-94(2004)
3. Kim HS, Ishizuka M, Kazusaka A, Fujita S. Alterations of activities of cytosolic phospholipase A2 and arachidonic acid-metabolizing enzymes in di-(2-ethylhexyl)phthalate-induced testicular atrophy. J. Vet. Med. Sci. 66 : 1119-1124(2004)
4. Saito K, Sakai N, Kim HS, Ishizuka M, Kazusaka A, Fujita S. Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats. Drug Metab. Dispos. 32 : 959-65(2004)
5. Shaban Z, El-Shazly S, Ishizuka M, Kimura K, Kazusaka A, Fujita S. PPARalpha-dependent modulation of hepatic CYP1A by clofibric acid in rats. Arch. Toxicol. 78 : 496-507(2004)
6. Saito K, Kim HS, Sakai N, Ishizuka M, Kazusaka A, Fujita S. Polymorphism in diazepam metabolism in Wistar rats. J. Pharm. Sci. 93 : 1271-1278(2004)

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Original Articles

1. Kim HS, Saito K, Ishizuka M, Kazusaka A, Fujita S. Short period exposure to di-(2-ethylhexyl) phthalate regulates testosterone metabolism in testis of prepubertal rats. Arch Toxicol., 77, 8 : 446-51(2003)
2. Sakamoto KQ, Nakai K, Aoto T, Yokoyama A, Ushikoshi R, Hirose H, Ishizuka M, Kazusaka A, Fujita S. Cytochrome p450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan. Chemosphere. 51, 6 : 491-500(2003)
3. Ishizuka M, Yonemoto J, Zaha H, Tohyama C, Sone H. Perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters sex-dependent expression of hepatic CYP2C11. J Biochem Mol Toxicol., 17, 5 : 278-85(2003)
4. Hoshino H, Fujita S, Goto Y, Isono T, Tsuyoshi I, Yasunori S. Organochlorine compound accumulation in Steller sea lion Eumetopias jubatus migrating along the coast of Hokkaido in northern Japan.
   Jpn J Toxicol. 6, 1 : 1-10(2003)

▲このページの先頭へ

1. Sakamoto KQ, Nakai K, Aoto T, Yokoyama A, Ushikoshi R, Hirose H, Ishizuka M, Kazusaka A, Fujita S. Cytochrome P450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan. Chemosphere. 51(6):491-500(2003)
2. Tilley RE, Kemp GD, Teramitsu I, Hall AJ. Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus). Comp Biochem Physiol C Toxicol Pharmacol. 132(2) 181-191(2002)
3. Sakamoto KQ, Kunisue T, Watanabe M, Masuda Y, Iwata H, Tanabe S, Akahori F, Ishizuka M, Kazusaka A, Fujita S. Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller’s sea eagles and white-tailed sea eagles, threatened species, in Hokkaido, Japan. Environ Toxicol Chem. 21(4):842-7(2002)
4. Chiba I, Sakakibara A, Iwata TH, Ishizuka M, Tanabe S, Akahori F, Kazusaka A, Fujita S. Hepatic microsomal cytochrome p450s and chlorinated hydrocarbons in largha and ribbon seals from Hokkaido, Japan: differential response of seal species to Ah receptor agonist exposure. Environ Toxicol Chem. 21(4):794-806(2002)
5. 石塚真由美、藤田正一　「化学物質による野生生物及び生態系への影響とは」化学物質と環境 58:7-10(2003)

Publications other than original articles

1. 石塚真由美、岩田久人、藤田正一：トキシコロジー7章　環境毒性（日本トキシコロジー学会）（290-303）(2002)
2. 板倉隆夫、石塚真由美、藤田正一：シトクロムP450（講談社サイエンティフィク)
3. 藤田正一「臨床薬物代謝化学」（廣川書店）
4. Ishizuka M. Yamamoto Y. Takada A. Kazusaka A. Fujita S. The loss of enzyme activities by a single amino acid substitution of a newly cloned rabbit CYP2D isozyme, CYP2D24. International Congress Series. 1223:121-126(2002)

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Original Articles

1. Sakamoto QK, Kunise T, Watanabe M, Masuda Y, Iwata H, Tanabe S, Akahori F, Ishizuka M, Kazusaka A, Fujita S. Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller’s sea eagles and White-tailed sea eagles, threatened species, in Hokkaido, Japan. Environ Toxicol Chem. 21(4):842-7(2002)
2. Chiba I, Sakakibara A, Iwata H, Ishizuka M, Tanabe S, Kazusaka A, Fujita S. Hepatic microsomal cytochrome P450s and chlorinated hydrocarbons in largha and ribbon seals from Hokkaido, Japan: Differential response of seal species to Ah receptor agonist exposure. Environ Toxicol Chem. Apr;21(4):794-806(2002)
3. Maruyama Y, Suzuki Y, Kazusaka A, Fujita S. Uptake of the dopaminergic neurotoxin, norsalsolonol, into PC12 cells via dopamine transpoter. Archives of toxicology. 75(4):209-13(2001)
4. Teraoka H, Maruyama Y, Takehana K, Iwanaga T, Hiraga T, Fujita S, Ohta T. Ca(2+) signaling in porcine duodenal glands by muscarinic receptor activation. Am J Physiol Gastrointest Liver Physiol. 280(4):G729-37(2001)
5. Maruyama Y, Suzuki Y, Kazusaka A, Fujita S. Norsalsolinol uptake into secretory vesicles via vesicular monoamine transporter and its secretion by membrane depolarization or purinoceptor stimulation in PC12 cells.　J Vet Med Sci. 63(5):493-7(2001)
6. Chiba I, Sakakibara A, Goto Y, Isono T, Yamamoto Y, Iwata H, Tanabe S, Shimazaki K, Akahori F, Kazusaka A, Fujita S. Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seal from the coast of Hokkaido, Japan.? Environ Toxicol Chem. 20(5):1092-7(2001)
7. Fujita S, Chiba I, Ishizuka M, Hoshi H, Iwata H, Sakakibara A, Tanabe S, Kazusaka A, Masuda M, Masuda Y, Nakagawa H. P450 in wild animals as biomarker of environmental impact. Biomarkers 6(1):13-25(2001)
8. Yamamoto H, Watanabe T, Mizuno H, Endo K, Fukushige J, Hosokawa T, Kazusaka A, Fujita S. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 34(1):69-80(2001)
9. Yamamoto H, Watanabe T, Mizuno H, Endo K, Hosokawa T, Kazusaka A, Gooneratne R, Fujita S. In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. Free Radic Biol Med. 30(5):547-54(2001)
10. Maruyama Y, Teraoka H, Iwata H, Kazusaka A, Fujita S. Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochem Int. 38(7):567-572(2001)

▲このページの先頭へ

1. Chiba I, Sakakibara A, Goto Y, Isono T, Yamamoto Y, Iwata H, Tanabe S, Shimazaki K, Akahori F, Kazusaka A,
   Fujita S. Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seal from the coast of Hokkaido, Japan.? (Environ Toxicol Chem. 20(5):1092-7(2001)
2. Fujita S, Chiba I, Ishizuka M, Hoshi H, Iwata H, Sakakibara A, Tanabe S, Kazusaka A, Masuda M, Masuda Y, Nakagawa H. P450 in wild animals as biomarker of environmental impact. Biomarkers 6(1):13-25(2001)
3. Teramitsu I, Yamamoto Y, Chiba I, Iwata H, Tanabe S, Fujise Y, Kazusaka A, Akahori F, Fujita S. Identification of novel cytochrome P450 1A genes from five marine mammal species. Aquat Toxicol. Dec 1;51(2):145-153(2000)
4. Yamamoto H, Watanabe T, Mizuno H, Endo K, Fukushige J, Hosokawa T, Kazusaka A, Fujita S. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 34(1):69-80(2001)
5. Yamamoto H, Watanabe T, Mizuno H, Endo K, Hosokawa T, Kazusaka A, Gooneratne R, Fujita S. In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. Free Radic Biol Med. 30(5):547-54(2001)
6. Maruyama Y, Teraoka H, Iwata H, Kazusaka A, Fujita S. Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochem Int. 38(7):567-572(2001)
7. Yoon S, Kazusaka A, Fujita S. FTIR spectroscopic and HPLC chromatographic studies of carbon tetrachloride induced acute hepatitis in rats: damage in liver phospholipid membrane. Biopolymers. 57(5):267-71(2000)
8. Yoon S, Maruyama Y, Kazusaka A, Fujita S. Application of FT-IR and ESR spectroscopic techniques to the study of CCl4-induced peroxidation in rat liver microsomes. Jpn J Vet Res. Feb;47(3-4):151-4(2000)
9. Yoon S, Maruyama Y, Kazusaka A, Fujita S. Accumulation of diacylglycerol induced by CCl4-derived radicals in rat liver membrane and its inhibition with radical trapping reagent–FT-IR spectroscopic and HPLC chromatographic observations. Jpn J Vet Res. 47(3-4):135-44(2000)

▲このページの先頭へ

Original Articles

1. Nakamura A, Hirota T, Morino A, Imaoka ., Funae Y, Yamamota Y, Tasaki T, Masuda M, Kazusaka A, and Fujita S. Cylochrome P-450 isoforms responsible for the N-demethylation an d cyclohexane-hydroxylation of NS-21. Xenobiotica, 29 : 243-252(1999)
2. Shimamoto Y, Tasaki T, Kitamura H, Hirose K, Kazusaka A, and Fujita S. Decrease in hepatic CYP 2 C11 mRNA and increase in heme oxygenase activity after intracerebroventricular injection of bacterial endotoxin. J. Vet. Med. Sci.,61 : 609-613(1999)
3. Shimamoto Y, Kitamura H, Iwai M, Saito M, Kazusaka A, and Fujita S. Mechanism of decresae in levels of hepatic P450 isozymes induced by intracerebral endotoxin. Arch. Toxicol . , 73 : 41-49(1999)
4. Yamamoto H, Hirose K, Hayasaki Y, Masuda M, Kazusaka A, and Fujita S. Mechanism of enhanced lipid peroxidation in the liver of Long-Evance cinnamon (LEC) rats. Arch. Toxicol., 73 : 457-464(1999)
5. Kblood EBM, Miyoshi H, Iwata H, Kazusaka A, Kon Y, Handid AHA, Moustafe EK, Ghomin MH, and Fujita S. Effects of concurrent exposure to 3 -methylcholanthrene and vitamin A on fetal development in rats. Jpn. J. Vet. Res.,47 : 13-23(1999)
6. Takahashi J, Furuhata Y, Ikeda A, Takahashi M, Iwata H, Kazusaka A, and Fujita S. Characterization of hepatic cyiochrome P450 isozyme composition in the transgenic rat expressing low level human growth hormone. Xenobiotica, 29 : 1203-1212(1999)
7. Kim E-Y, Goto R, Iwata H, Masuda Y, Tanabe S, and Fujita S. Preliminary survey of, Iead poisoning of steller’s sea eagle ( Haliaeetus pelagicus) and White-tailed sea eagle (Haliaeetus albicilla) in Hokkaido, Japan. Environmental Toxicology and Chemistry, 18 : 448-451(1999)
8. Fujita S. Experimental use of debate in a science class. J. Higher Education and Lifelong Learning, 5 : 74-91(1999, in Japanese with English Summary)

Publications other than original articles

1. Yoon S, Kazusaka A, and Fujita S. Infrared spectroscopic study on the mechanism of CC14 toxicity toward membrane phospholipids from rat liver. J. Toxicol. Sci., 24, 370(1999)
2. Maruyama Y, Suzuki Y, Teraoka H, lwata H, Kazusaka A, and Fujita S. Norsalsolinol, an endogeneous dopaminergic neurotoxin , inhibits dopamine secretion in PC12 cells. J. Toxicol. Sci., 24, 358(1999)
3. Chiba I, Sakakibara A, Iwata H, Tanabe S, Kazusaka A, and Fujita S. Seal liver P450, as a marker enzyme for marine pollution. J. Toxicol. Sci., 24, 301(1999)
4. Yoon S, Kazusaka A, and Fujita S. FT-IR observation of conformational change in the rat liver phosphol-ipid with spontaneous or chemical in-duced hepatitis. Fourier Transform Spectroscopy, 12th International Conference, pp475-476(1999)
5. Sasaki I, Kawanabe A, Yamakawa I, Kazusaka A, Yoon S, and Fujita S. In vivo observation of cylochrome P450 1 A isozyme reaction in liver of living rats by using fiberoptic sensor. Proceedings of 13th international conference on optical fiber sensor, Seoul, Korea(1999)

▲このページの先頭へ

Original Articles

1. Tasaki T, Nakamura A, Itoh S, Ohashi K, Yamamoto Y, Masuda M, Iwata H, Kazusaka A, Kamataki T, Fujita S. Expression and characterization of dog CYP2D15 using baculovirus expression system. J. Biochem. 123, 162-168 (1998)
2. Ishizuka M, Sakiyama T, Iwata H, Fukushima M, Kazusaka A, Fujita S. Accumulation of halogenated aromatic hydrocarbons and activities of cytochrome P450 and glutathione S-transferase in crabs (Eriocheir japonicus) from Japanese rivers. Environmental Toxicology and Chemistry 17, 1490-1498 (1998)
3. Yamamoto Y, Tasaki T, Nakamura A, Iwata H, Kazusaka A, Gonzalezb FJ, Fujita S. Molecular basis of the dark agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2. Pharmacologenetics 8, 73-82 (1998)
4. Yamamoto Y, Ishizuka M, Takada A, Fujita S. Cloning, tissue distribution, functional expression of novel rabbit cytochrome P450 isozymes, CYP2D23 and CYP2D24. J. Biochem., 124, 503-508 (1998)
5. Tasaki T, Iwata H, Kazusaka A, Fujita S. Regio- and stereoselectivity in propranolol metabolism by dog liver microsomes and dog CYP2D15. J. Biochem. 123, 747-751 (1998)
6. Hoshi H, Minamoto N, Iwata H, Shiraki K, Tatsukawa R, Tanabe S, Fujita S, Hirai K, Kinjyo T. Organochlorine pesticides and polychlorinated biphenyl congeners in wild terrestrial mammals and birds from Chubu region, Japan: Interspecies comparison of the residue levels and compositions. Chemosphere, 36, 3211-3221 (1998)
7. Ishizuka M, Iwata H, Hatakeyama S, Kazusaka A, Fujita S. Effects of the agrochemicals butachlor, pretiolachlor and isoprothiolaane on rat liver xenobioticmetabolizing enzymes. Xenobiotica, 11, 1029-1039 (1998)
8. Morita K, Maeda Y, Masuda M, Kazusaka A, Fujita S. Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Biochem. Pharmacol., 55, 1405-1411 (1998)
9. Iwata H, Tanabe S, Iida T, Baba N, Ludwig JP, and Tatsukawa R. Enantioselective accumulation of alpfa-hexachlorocyclohexane in northern furseals and double-crested cormorants: Effects of biological and ecological factors in the higher trophic levels. Environ. Sci. Technol., 32, 2244-2249 (1998)
10. Shimamoto Y, Kitamura H, Hoshi H, Kazusaka A, Funae Y, Imaoka S, Saito M, Fujita S. Differential alteration of microsomal cytochrome P450 levels in rat liver microsomes following intracerebral injection of bacterial lipopolysaccharide. Archive of Toxicology, 72, 492-498 (1998)

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Original Articles

1. Ishizuka M, Yoshino S, Yamamoto Y, Yamamoto H, Imaoka S, Funae Y, Iwata H, Masuda M, Kazusaka A, and Fujita S. Pathway-selective alteration of imipramine metabolism during regeneration of male rat liver following partial hepatectomy. Xenobiotica, 27 : 923-931(1997)
2. Maeda Y, Morita K, Tasaki T, Masuda M, Kazusaka A, and Fujita S. Strain differences in testosterone metabolism in Wistar and Dark Agouti rats.-A new polymorphism-. Environ. Toxicol. Pharmacol., 3 : 1-6(1997)
3. Maeda Y, Taira T, Haraguchi K, Hirose K, Kazusaka A, and Fujita S. Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. Cancer Lett., 119 : 137-141(1997)
4. Iwata H, Tanabe S, Mizuno T, and Tatsukawa R. Bioaccumulation of butyltin compounds in marine mammals: Their tissue distribution and composition. Appl. Organomet. Chem., 11 : 257-264(1997)
5. Guruge KS, Iwata H, Tanaka H, and Tanabe S. Accumulation of butyltins in the liver and kidney of seabirds. Mar. Environ. Res., 44 : 191-199(1997)
6. Tasaki T, Nakamura A, Itoh S, Ohashi K, Yamamoto Y, Masuda M, Iwata H, Kazusaka A, Kamataki T, and Fujita S. Expression and characterization of dog CYP2D15 using baculovirus expression system. J. Biochem., 123 : 162-168(1998)
7. Yamamoto Y, Tasaki T, Nakamura A, Iwata H, Kazusaka A, Gonzalez FJ, and Fujita S. Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Involvement of CYP2D1 and CYP2D2. Pharmacogenetics, 8 : 73-82(1998)

Publications other than original articles

1. Fujita S. Current status of university entrance examination and its impact on the education. J. Higher Education (Hokkaido Univ.), 2 : 171-179(1997, in Japanese)
2. Iwata H, Watanabe M, Tanabe S, Masuda Y, Masuda M, Kazusaka A, and Fujita S. High level of chlorinated hydrocarbons found in Stellars sea eagles found dead in Shiretoko Peninsula. Annual Report of Shiretoko Museum, 18 : 1-7(1997, in Japanese)
3. Hoshi H. A method for monitoring environmental contamination-Environmental monitoring using wild rodent’s P450 as an indicator-. Jpn. J. Zoo Wild. Med., 2 : 9-12(1997, in Japanese)

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Original Articles

1. Fujita S, Masuda M, Shimamoto Y, Hoshi H, Kariya S, Kazusaka A. and Suzuki T. Effect of 3-methylcholan-threne on bunitrolol metabolism: Kinetics and immunological studies on 4-hydroxylation of bunitrolol catalyzed by two species of cytochromes P450 in rat liver microsomes. Drug Metab. Dispos., 24: 254-259(1996)
2. Ishizuka M, Hoshi H, Minamoto N, Masuda M, Kazusaka A. and Fujita S. Alterations of cytochrome P450 dependent monooxygenase activities in Eriocheir japonicus in response to water pollution. Environ. Health Persp., 104: 774-778(1996)
3. Yamamoto Y, Nakamura A, Tasaki T, Umeda S, Sugimoto C, Imaoka S, Funae Y, Masuda M, Kazusaka A. and Fujita S. Impaired expression in DA rats of catalytically active P450BTL, immunochemically distinguishable from P4502D1: Immunological evidence with specific anti-peptide antibodies. Biomed. Res., 17: 331-337(1996)
4. Hatakeyama S, Hayasaki Y, Masuda M, Kazusaka A. and Fujita S. Mechanism for mouse strain differences in the protective effect of Sudan III against the in vivo genotoxicity of 7, 12-dimethylbenz-(a)anthracene. Toxicol. Lett., 89: 231-239(1996)
5. Tanabe S, Kummran P, Iwata H, Tatsukawa R. and Miyazaki N. Enantiomeric ratios of alpha-hexachlorocyclohexane in blubber of small cetaceans. Mar. Pollut. Bull., 32: 27-31(1996)
6. Kim GB, Lee JS, Tanabe S, Iwata H, Tatsukawa R. and Shimazaki K. Specific accumulation of butyltin compounds in various organs and tissues of steller sea lion (Eumetopias jubatus): Comparison with organochlorine compounds. Mar. Pollut. Bull., 32: 558-563(1996)
7. Guruge KS, Tanabe S, Iwata H, Tatsukawa R. and Yamagishi S. Distribution, biomagnification, and elimination of butyltin compound residues in common cormorant (Phalacrocorax carbo) from Lake Biwa, Japan. Arch. Environ. Contam. Toxicol., 31: 210-217(1996)

Publications other than original articles

1. Fujita S. Inhibition of cytochrome P450. Jpn. J. Toxicol., 9: 149-158 (1996, in Japanese).
2. Fujita S. Opinions of the teaching staff of Hokkaido university on the evaluation of their lectures by students. J. Higher Education (Hokkaido Univ.), 1: 81-104 (1996, in Japanese).
3. Fujita S. Students’ evaluation of the lectures of Hokkaido university. Tsukuba Forum, 45: 28-34 (1996, in Japanese).
4. Kazusaka A. Thinking about environmental science. J. Environmental Protection Center of Hokkaido University, 5: 9-12 (1996, in Japanese).
5. Kazusaka A. One biological reaction occurred by copper ions. Shokubai, 38: 316-317 (1996, in Japanese).
6. Iwata H. and Tatsukawa, R. Marine pollution by organochlorines. In: Civilization and Environment: Environmental Crisis and Modern Civilization, pp. 114-129, Ishi, H. and Numata, S. eds., Asakura Press, Tokyo (1996, in Japanese).
7. Iwata H, Ishizuka M. and Fujita S. Animal as a indicator of highly toxic organic pollutants: Availability of biomarker to detect environmental pollution. J. Vet. Med., 49: 665-669 (1996, in Japanese).
8. Iwata H, Tanabe S. and Tatsukawa R. Accumulation of organotin compounds in higher trophic animals. In: Proceedings of Otsuchi Manne Research Center Report, Vol. 21, pp. 61-62, Iwate (1996, in Japanese).

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